Progression and direction of contractures of knee joints following spinal cord injury in the rat

The Tohoku Journal of Experimental Medicine
H MoriyamaY Tobimatsu

Abstract

Joint contractures following central nervous system injuries remain a prevalent and significant complication, but no reports are available on evidence of contracture formation over time. The objective of this study was to determine the rate of contracture progression and the direction of loss in joint movement following spinal cord injuries (SCI). Forty-eight female Wistar rats were used. Twenty-four experimental rats underwent a spinal cord transection at the level of T8 and 24 control rats underwent a sham-operation. The animals were studied at each of 5 time points: 2, 4, 8, 12, 16, and 24 weeks after surgical intervention. The degree of contractures was assessed by measuring the femorotibial angle on both hindlimbs with the use of a goniometer. Knee joint motion was measured for flexion and extension direction. Knee flexion contractures developed in all experimental rats. The restriction in motion progressed during the first 12 weeks and plateaued thereafter. The contractures were produced almost exclusively by a loss in the extension range of motion. This study defined the time course that contracture progression was more rapid in the early stage after SCI and stabilized in the later stage of injury. Contractures following...Continue Reading

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Citations

Jan 24, 2009·Journal of Neurophysiology·V F LyalkaT G Deliagina
Aug 19, 2007·Osteoarthritis and Cartilage·H MoriyamaY Tobimatsu
Nov 1, 2016·Clinical Orthopaedics and Related Research·Hiroyuki IwasawaHideki Moriyama
Jul 31, 2013·Clinical Orthopaedics and Related Research·Hideki MoriyamaRyo Tanaka
May 29, 2019·Clinical Orthopaedics and Related Research·Shota InoueToshihiro Akisue
Jun 16, 2019·Spinal Cord·Hideki MoriyamaToshihiro Akisue
May 23, 2017·Calcified Tissue International·Naoyoshi SakitaniHideki Moriyama

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