Progression from preplus to plus disease in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study: incidence, timing, and predictors.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Qianqian Ellie Chenge-ROP Cooperative Group

Abstract

To determine the incidence of and timing and predictors for progression from pre-plus to plus disease, based on evaluation of images. Two trained readers independently evaluated posterior pole images of infants from 13 North American centers for pre-plus/plus disease, stage, and zone of retinopathy of prematurity (ROP). Discrepancies between readers were adjudicated. To be eligible for analysis, eyes had to have at least two imaging sessions, the earlier one with pre-plus disease. Of 681 eyes of 444 infants with pre-plus first detected at mean postmenstrual age (PMA) of 35.5 ± 2.1 weeks, 54 (7.9%) progressed to plus disease at a mean PMA of 37.6 ± 2.4 weeks with the mean interval for progression of 2.7 weeks (range, 0.4-8.9 weeks). Progression rate was higher for eyes with larger number of quadrants of pre-plus (44% for eyes with four quadrants vs 4% with one quadrant [P < 0.0001]), earlier PMA with pre-plus (18% for 32 weeks' PMA vs 3% for PMA of >37 weeks [P = 0.02]), higher ROP stage (12% for stage 3, 2.5% for no ROP [P < 0.0001]), lower ROP zone (24% for zone I, 6% for zone II or no ROP [P < 0.0001]) at the time of first pre-plus detection. Based on image evaluation, 8% of eyes progressed from pre-plus to plus disease at a ...Continue Reading

References

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Jun 28, 2014·JAMA Ophthalmology·Graham E QuinnUNKNOWN e-ROP Cooperative Group
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Aug 11, 2017·JAMA Ophthalmology·Graham E QuinnUNKNOWN Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity Cooperative Group

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