Progression in Fontan conduit stenosis and hemodynamic impact during childhood and adolescence.

The Journal of Thoracic and Cardiovascular Surgery
Neil D PatelAndrew L Cheng

Abstract

To characterize changes in Fontan conduit size over time and determine if cross-sectional area (CSA) affects cardiac output, pulmonary artery growth, and exercise capacity. We conducted a retrospective cross-sectional study of patients with Fontan physiology who underwent cardiac magnetic resonance imaging or cardiac catheterization between January 2013 and October 2019. We collected Fontan and pulmonary artery measurements, hemodynamic data, and cardiopulmonary exercise test data. We identified 158 patients with an extracardiac Fontan. We measured minimum and mean Fontan conduit CSA and assessed whether these correlated with Nakata index, cardiac index, or exercise capacity. Minimum Fontan CSA decreased by a median of 33% (24%, 40%) during a mean follow-up of 9.6 years. Median percentage decrease in Fontan CSA did not differ among 16-, 18-, and 20-mm conduits (P = .29). There was a significant decrease in the minimum Fontan CSA (33% [25%, 41%]) starting less than 1-year post-Fontan. Median Nakata index was 177.6 mm2/m2 (149.1, 210.8) and was not associated with Fontan CSA/BSA (ρ = 0.09, P = .29). Fontan CSA/BSA was not associated with cardiac index (ρ = -0.003, P = .97). A larger Fontan CSA/BSA had a modest correlation with % ...Continue Reading

References

May 1, 1971·Thorax·F Fontan, E Baudet
Feb 1, 1984·The American Review of Respiratory Disease·D M Cooper, D Weiler-Ravell
Jan 22, 1998·The Journal of Thoracic and Cardiovascular Surgery·A AmodeoC Marcelletti
Dec 13, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·V Alexi-MeskishviliR Hetzer
Dec 15, 2005·Heart, Lung & Circulation·U K ChowdhuryP Venugopal
Apr 10, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Cheul LeeWoong-Han Kim
Jul 5, 2008·Journal of the American College of Cardiology·Stephen M ParidonUNKNOWN Pediatric Heart Network Investigators
Feb 24, 2009·The Annals of Thoracic Surgery·Stanislav OvroutskiFelix Berger
Jul 28, 2009·The Annals of Thoracic Surgery·Keiichi ItataniMasahiro Ishii
Nov 17, 2009·Pediatric Cardiology·Susan M FernandesJonathan Rhodes
Nov 28, 2013·Heart Failure Clinics·Marc Gewillig, David J Goldberg
Feb 18, 2014·The Annals of Thoracic Surgery·Anja LehnerKatarzyna Januszewska
May 13, 2014·Pediatric Cardiology·William N EvansHumberto Restrepo
Jul 27, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Fuyou LiangHao Liu
Dec 3, 2014·The Annals of Thoracic Surgery·Maria RestrepoAjit P Yoganathan
Feb 27, 2017·Heart·Floris E A Udink Ten CateNarayanswami Sreeram
Mar 21, 2017·The Journal of Thoracic and Cardiovascular Surgery·Leo A BockeriaThierry Carrel
Aug 31, 2018·Translational Pediatrics·Frank Cetta, Harold M Burkhart
Feb 26, 2019·Congenital Heart Disease·Donald J HaglerNathaniel W Taggart

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Citations

Dec 22, 2020·The Journal of Thoracic and Cardiovascular Surgery·Aybala Tongut, Yves d'Udekem
Nov 22, 2020·The Journal of Thoracic and Cardiovascular Surgery·Awais Ashfaq, James S Tweddell
Nov 23, 2020·The Journal of Thoracic and Cardiovascular Surgery·Andrew Well, Ziv Beckerman
Nov 9, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Friso M RijnbergArno A W Roest

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