Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection

BMC Infectious Diseases
Dimitrios SinapidisEvangelos J Giamarellos-Bourboulis

Abstract

Development of sepsis is a process with significant variation among individuals. The precise elements of this variation need to be defined. This study was designed to define the way in which comorbidities contribute to sepsis development. Three thousand five hundred nine patients with acute pyelonephritis (AP), community-acquired pneumonia (CAP), intraabdominal infections (IAI) or primary bacteremia (BSI) and at least two signs of the systemic inflammatory response syndrome were analyzed. The study primary endpoint was to define how comorbidities as expressed in the Charlson's comorbidity index (CCI) and the underlying type of infection contribute to development of organ dysfunction. The precise comorbidities that mediate sepsis development and risk for death among 18 comorbidities recorded were the secondary study endpoints. CCI more than 2 had an odds ratio of 5.67 for sepsis progression in patients with IAI between significantly higher than AP and BSI. Forward logistic regression analysis indicated seven comorbidities that determine transition into sepsis in patients with AP, four comorbidities in CAP, six comorbidities in IAI and one in BSI. The odds ratio both for progression to sepsis and death with one comorbidity or wit...Continue Reading

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Citations

Sep 22, 2018·Current Opinion in Critical Care·Catia CillónizAntoni Torres
Jan 15, 2019·Current Opinion in Infectious Diseases·Marin H Kollef, Kevin D Betthauser
Jul 5, 2019·Journal of Clinical Medicine·Catia CillónizAntoni Torres
Sep 11, 2019·Medical Sciences : Open Access Journal·Artem RigaYuriy Grirorov
Sep 5, 2020·Metabolites·Giovana Colozza MecattiPatrícia de Oliveira Carvalho
Oct 2, 2020·Scientific Reports·Chloé Albert VegaSophie Trouillet-Assant
Nov 21, 2020·BMC Infectious Diseases·Sarantia DoulouEvangelos J Giamarellos-Bourboulis
Dec 12, 2020·Computational and Structural Biotechnology Journal·Waqas KhaliqMichael Bauer
Jul 28, 2021·Critical Care Medicine·Mohammad AlrawashdehUNKNOWN CDC Prevention Epicenters Program

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Methods Mentioned

BETA
genotyping

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