Progression of Aortic Arch Calcification Is Associated with Overall and Cardiovascular Mortality in Hemodialysis.

Disease Markers
Wei-Shiuan ChungHung-Chun Chen

Abstract

Vascular calcification is common and associated with unfavorable outcomes among patients with end-stage renal disease (ESRD). Nevertheless, little is known whether the progression of vascular calcification outweighs the baseline calcification in association with overall and cardiovascular (CV) mortality in hemodialysis (HD) patients. This study included 140 maintenance HD patients. Vascular calcification was assessed using the aortic arch calcification (AoAC) score measured from chest radiographs at the baseline and the second year of follow-up. Progression of vascular calcification (ΔAoAC) was defined as the difference between the two measurements of AoAC. The association of ΔAoAC with overall and CV mortality was evaluated using multivariate Cox regression analysis. During the mean follow-up period of 5.8 years, there were 49 (35%) overall mortality and 27 (19.3%) CV mortality. High brachial-ankle pulse wave velocity was positively correlated with ΔAoAC, whereas old age was negatively correlated with ΔAoAC. In multivariate adjusted Cox analysis, increased ΔAoAC (per 1 unit), but not baseline AoAC, was significantly associated with overall mortality (HR, 1.183; 95% CI, 1.056-1.327; p = 0.004) and CV mortality (HR, 1.194; 95% C...Continue Reading

References

Nov 14, 1997·Kidney International·J T DaugirdasG Schulman
May 18, 2000·The New England Journal of Medicine·W G GoodmanI B Salusky
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A J CollinsC Herzog
Feb 19, 2002·Journal of the American College of Cardiology·Paolo RaggiGlenn M Chertow
Aug 26, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gérard M LondonHasan Adda
Apr 7, 2004·Clinical and Experimental Nephrology·Mitsuteru MatsuokaShuichi Takishita
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Susan J ZiemanDavid A Kass
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Marcello TonelliAmit X Garg
Oct 12, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Mhairi K SigristChristopher W McIntyre
Jan 11, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Peter StenvinkelZiad Massy
Jun 3, 2009·Hemodialysis International·Tetsuya OgawaKosaku Nitta
Dec 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paolo RaggiUNKNOWN ADVANCE Study Group
Jun 11, 2011·International Journal of Nephrology·Cai-Mei ZhengYuh-Feng Lin
Jun 11, 2011·International Journal of Nephrology·Antonio BellasiCarlo Ratti
Apr 26, 2012·Current Opinion in Nephrology and Hypertension·Antonio Bellasi, Paolo Raggi
Nov 6, 2012·The New England Journal of Medicine·UNKNOWN EVOLVE Trial InvestigatorsPatrick S Parfrey
May 21, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Biagio Di IorioUNKNOWN INDEPENDENT Study Investigators
Aug 22, 2014·American Journal of Physiology. Renal Physiology·Neil J Paloian, Cecilia M Giachelli
Jan 13, 2015·Kidney & Blood Pressure Research·Mizuki KomatsuKosaku Nitta
Apr 4, 2015·Journal of the American Society of Nephrology : JASN·Hartmut H MallucheDaniel L Davenport
Aug 1, 2016·Seminars in Nephrology·Alan S Go
Aug 9, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ching-Fang WuTze-Wah Kao
Nov 17, 2016·Bone·Shunsuke Yamada, Cecilia M Giachelli
Mar 24, 2017·Seminars in Dialysis·Paolo Raggi, W Charles O'Neill
Sep 15, 2017·Contributions to Nephrology·Mario CozzolinoFerruccio Conte
Aug 29, 2018·Kidney & Blood Pressure Research·Szu-Chia ChenHung-Chun Chen

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