PMID: 9420620Jan 8, 1998Paper

Progression of articular destruction and the production of tumour necrosis factor-alpha in antigen-induced arthritis in rabbits

Scandinavian Journal of Immunology
H IdogawaM Ohashi

Abstract

We examined the progression of articular destruction and the production of tumour necrosis factor-alpha (TNF-alpha) in antigen-induced arthritis (AIA) in rabbits, i.e. flare-ups of inflammation induced by repeated intra-articular injections (single, twice and three times) of antigen. A marked progression of articular destruction and an infiltration of inflammatory cells in the synovium were observed with the increase in the number of antigen injections. An immunohistochemical analysis of the synovial lesions following three injections of antigen revealed that the lymphoid follicles consisted mainly of CD4+ T cells and IgG/IgM+ B cells. There were marked infiltrations of IgG+ plasma cells around the lymphoid follicles. In contrast, the production of TNF-alpha in the synovial fluid and the erythrocyte sedimentation rate (ESR), which is a marker of systemic inflammatory activity in rheumatoid arthritis, peaked at 6 h 24 h, respectively, following the last injection of antigen. These values were also greater following the repeated injections of antigen compared with the single injection. The TNF-alpha was produced markedly in the joints at the onset of the flare-ups of arthritis following the repeated injections of antigen, and the...Continue Reading

Citations

Aug 23, 2003·Arthritis Research & Therapy·Sharon D LuikartTheodore Oegema
Sep 8, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Kasper D KristensenTroels Herlin
Aug 4, 2004·European Journal of Pharmacology·Gustavo BombiniFernando Q Cunha
Apr 7, 2006·European Journal of Pharmacology·Mariana L ValeRonaldo A Ribeiro

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.