Abstract
The purpose of the present study was to assess the short- and long-term progression of cardiac allograft vasculopathy (CAV) using serial 3-vessel quantitative coronary angiography (QCA). CAV progression was assessed using serial 3-vessel QCA analysis at baseline, 1-year and long-term angiographic follow-up (8.5±3.7 years) after heart transplantation. The change in minimal lumen diameter (MLD) and percent diameter stenosis (%DS) was serially assessed within matched segments. Patients were graded according to the ISHLT-CAV classification and grouped as ISHLT-CAV0 and ISHLT-CAV1-3. The primary endpoint was mean change in MLD and %DS. A total of 41 patients and 520 matched segments were available for serial 3-vessel QCA. Overall, MLD decreased non-significantly from baseline to 1-year follow-up and significantly from 1-year to the long-term angiographic follow-up (Δ-0.08mm/year [95%CI -0.11 to -0.05], P<0.001). %DS increased significantly from baseline to 1-year (Δ+0.96%/year [95%CI 0.04 to 1.88], P = 0.041) and from 1-year to long-term angiographic follow-up (Δ+0.61%/year [95%CI 0.33 to 0.88], P<0.001). ISHLT-CAV1-3 at 1 year and at long-term angiographic follow-up was observed in 22% and 61%, respectively. Between baseline and lo...Continue Reading
References
Apr 11, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C WongA C Yeung
May 14, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Hiroshi TsutsuiE Murat Tuzcu
Oct 31, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Peter N RuygrokAnne Keogh
May 3, 2005·Journal of the American College of Cardiology·Jon A KobashigawaNathalie Cretin
May 3, 2005·Journal of the American College of Cardiology·E Murat TuzcuSteven E Nissen
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susan StewartMargaret E Billingham
Oct 14, 2006·Circulation Research·Maziar RahmaniBruce M McManus
Jul 21, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Maria Rosa CostanzoUNKNOWN International Society of Heart and Lung Transplantation Guidelines
Dec 16, 2011·Clinical Transplantation·J R BragaH J Ross
Sep 15, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Josef StehlikUNKNOWN International Society of Heart and Lung Transplantation
May 18, 2013·JACC. Cardiovascular Imaging·Ari PollackGiora Weisz
Mar 19, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S AroraUNKNOWN SCHEDULE (SCandinavian HEart transplant everolimus De novo stUdy with earLy calcineurin inhibitors avoidancE) Investigators
May 6, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Juan F DelgadoCarlos Lumbreras
Jun 5, 2015·European Heart Journal·Masanori TaniwakiLorenz Räber
Oct 12, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lars H LundJosef Stehlik
Dec 26, 2015·BMC Infectious Diseases·Inger JohanssonVilborg Sigurdardottir
Feb 18, 2017·Current Opinion in Cardiology·Kevin J ClerkinDonna M Mancini