Progression of cartilage degeneration and clinical symptoms in obese and overweight individuals is dependent on the amount of weight loss: 48-month data from the Osteoarthritis Initiative

Osteoarthritis and Cartilage
A S GersingThomas M Link

Abstract

To investigate compositional cartilage changes measured with 3T MRI-based T2 values over 48 months in overweight and obese individuals with different degrees of weight loss (WL) and to study whether WL slows knee cartilage degeneration and symptom worsening. We studied participants from the Osteoarthritis Initiative with risk factors or radiographic evidence of mild to moderate knee osteoarthritis with a baseline BMI ≥25 kg/m(2). We selected subjects who over 48 months lost a, moderate (BMI change, 5-10%WL, n = 180) or large amount of weight (≥10%WL, n = 78) and frequency-matched these to individuals with stable weight (<3%, n = 258). Right knee cartilage T2 maps of all compartments and grey-level co-occurrence matrix (GLCM) texture analyses were evaluated and associations with WL and clinical symptoms (WOMAC subscales for pain, stiffness and disability) were assessed using multivariable regression models. The amount of weight change was significantly associated with change in cartilage T2 of the medial tibia (β 0.9 ms, 95% CI 0.4 to 1.1, P = 0.001). Increase of T2 in the medial tibia was significantly associated with increase in WOMAC pain (β 0.5 ms, 95% CI 0.2 to 0.6, P = 0.02) and disability (β 0.03 ms, 95% CI 0.003 to 0.05,...Continue Reading

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Citations

Dec 27, 2016·Journal of Magnetic Resonance Imaging : JMRI·Thomas M LinkXiaojuan Li
Jan 19, 2017·The Journal of Bone and Joint Surgery. American Volume·Gwo-Chin Lee
Jun 19, 2018·Arthritis Care & Research·Stephen P MessierRichard F Loeser
Oct 3, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Valentina Pedoia, Sharmila Majumdar
Apr 6, 2018·The Open Orthopaedics Journal·Fred R T Nelson
May 10, 2020·Cells·Vineet Kumar MishraLiang-Yin Ke
Apr 13, 2018·Der Schmerz·T A Nees, M Schiltenwolf
Dec 19, 2018·Der Schmerz·T A NeesB Moradi
May 10, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Wenjin LiuChun Yuan
Jul 15, 2020·The Journal of Knee Surgery·Chad HanaokaPrakash Jayabalan
Jan 7, 2021·The New England Journal of Medicine·Leena Sharma
Jul 22, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alaleh RazmjooValentina Pedoia
May 17, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Xingzhong JinNatasha Nassar

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