Progression of change in NMDA, non-NMDA, and metabotropic glutamate receptor function at the developing corticothalamic synapse

Journal of Neurophysiology
P GolshaniE G Jones

Abstract

The development of receptor function at corticothalamic synapses during the first 20 days of postnatal development is described. Whole cell excitatory postsynaptic currents (EPSCs) were evoked in relay neurons of the ventral posterior nucleus (VP) by stimulation of corticothalamic fibers in in vitro slices of mouse brain from postnatal day 1 (P1). During P1-P12, excitatory postsynaptic conductances showed strong voltage dependence at peak current and at 100 ms after the stimulus and were almost completely antagonized by -2-amino-5-phosphonopentoic acid (APV), indicating that N-methyl--aspartate (NMDA) receptor-mediated currents dominate corticothalamic EPSCs at this time. After P12, in 42% of cells, excitatory postsynaptic conductances showed no voltage-dependence at peak current but still showed voltage-dependence 100-ms poststimulus. This voltage-dependent conductance was antagonized by APV. The nonvoltage-dependent component was APV resistant, showed fast decay, and was antagonized by the nonNMDA antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). In the remaining 58% of cells after P12, excitatory postsynaptic conductances showed moderate voltage dependence at peak conductance and strong voltage dependence 100 ms after...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D A McCormick, M von Krosigk
Mar 22, 1991·Proceedings. Biological Sciences·S Charpak, B H Gähwiler
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H E ScharfmanS M Sherman
Jan 1, 1986·Experimental Brain Research·S M Sherman, C Koch
Nov 22, 1988·Neuroscience Letters·Y Ben-AriK Krnjevic
Mar 11, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E G Jones, T P Powell
Jun 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J R WilsonS M Sherman
May 10, 1984·The Journal of Comparative Neurology·J A Robson
Dec 15, 1993·The Journal of Comparative Neurology·M WatanabeM Mishina
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·N Kato, H Yoshimura
Dec 21, 1995·Brain Research. Developmental Brain Research·C FrassoniR Spreafico

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Citations

Jan 11, 2002·Journal of Neurophysiology·Scott J CruikshankRaju Metherate
Jun 20, 2002·Science's STKE : Signal Transduction Knowledge Environment·Laurent FagniFabrice Ango
Mar 11, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T E Salt
Mar 18, 2005·Journal of Neurophysiology·Georgia M Alexander, Dwayne W Godwin
Sep 6, 2001·Journal of Neurophysiology·R B JacobsenJ R Huguenard
Mar 11, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Edward G Jones
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·P GolshaniE G Jones
Mar 11, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Vincenzo CrunelliStephen R Williams
May 14, 2004·Journal of Neurophysiology·Iva Reichova, S Murray Sherman
Oct 27, 2012·Journal of Neurophysiology·Francis LajeunesseIgor Timofeev
May 6, 2016·Journal of Neurophysiology·Charles G Frye, Jason N MacLean
Sep 1, 2016·Molecular Neurobiology·Witold Żakowski
Sep 6, 2007·PloS One·Basilis Zikopoulos, Helen Barbas
Jul 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yi Ping GuoJufang He
Dec 18, 2013·Physiological Research·E Szczurowska, P Mareš
Jun 22, 2006·Epilepsy Research·Georgia M Alexander, Dwayne W Godwin
Dec 17, 2005·Science·Carole E Landisman, Barry W Connors
Jul 23, 1998·The Journal of Comparative Neurology·E G JonesM M Huntsman

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