Progression of Colorectal Liver Metastases from the End of Chemotherapy to Resection: A New Contraindication to Surgery?

Annals of Surgical Oncology
Luca ViganòGuido Torzilli

Abstract

Not all patients with resectable colorectal liver metastases (CLM) benefit from liver resection (LR); only patients with disease progression during chemotherapy are excluded from surgery. This study was performed to determine whether tumor behavior (stable disease/progression) from the end of chemotherapy to LR impacts prognosis. Patients undergoing LR after tumor response or stabilization during chemotherapy were considered. Overall, 128 patients who underwent examination by two imaging modalities (computed tomography/magnetic resonance imaging) after chemotherapy with a > 3-week interval between the two imaging modalities were analyzed. Any variation in CLM size was registered. Tumor progression was defined according to the response evaluation criteria in solid tumors (RECIST) criteria. Among 128 patients with stable disease or partial response to preoperative chemotherapy, 32 (25%) developed disease progression in the chemotherapy to LR interval, with a disease progression rate of 17% when this interval was < 8 weeks. Survival was lower among patients with progression than those with stable disease [3-year overall survival (OS) 23.0 vs. 52.4%, and recurrence-free survival (RFS) 6.3% vs. 21.6%; p < 0.001]. Survival was extrem...Continue Reading

References

Apr 18, 2000·Archives of Surgery·L A LambertR J Barth
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N KokudoY Kato
Sep 2, 2006·Annals of Surgical Oncology·Chusilp CharnsangavejMichael A Choti
Aug 2, 2007·Annals of Surgery·Shaheen ZakariaDavid M Nagorney
Oct 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan B KesmodelBarry W Feig
Oct 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dan G BlazerJean-Nicolas Vauthey
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott KopetzRobert R McWilliams
Apr 24, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E GregoireD Azoulay
Sep 11, 2012·The Oncologist·René AdamUNKNOWN Jean-Nicolas Vauthey of the EGOSLIM (Expert Group on OncoSurgery management of LIver Metastases) group
Nov 15, 2012·The Journal of Surgical Research·Lisette T HoekstraThomas M van Gulik
Dec 3, 2014·The British Journal of Surgery·L ViganòG Mentha
Jul 25, 2015·The British Journal of Surgery·K W BrudvikJ-N Vauthey
Mar 13, 2016·Journal of the American College of Surgeons·Guillaume PassotJean-Nicolas Vauthey
Jun 19, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L ViganòR Adam
Jul 7, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemD Arnold
Aug 27, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Guido Torzilli, Matteo Maria Cimino

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Citations

Mar 21, 2018·Annals of Surgical Oncology·Eve Simoneau, Jean-Nicolas Vauthey
Jun 7, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M BinneböselU P Neumann
Aug 18, 2018·Gastroenterology Research and Practice·Ilenia BartoliniAntonio Taddei
Oct 11, 2020·Cancers·Francesco FizGuido Torzilli
May 16, 2018·Current Opinion in Oncology·Laura PolastroAlain Hendlisz
Sep 12, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Luca ViganòGuido Torzilli

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