Progression of corpus callosum atrophy in early stage of Alzheimer's disease: MRI based study.

Academic Radiology
Minwei ZhuZhiguo Lin

Abstract

Magnetic resonance imaging (MRI) studies reveal that atrophy of the corpus callosum (CC) is involved in early Alzheimer's disease (AD). The aim of this study was to investigate when and how callosal changes occur in the early course of AD. The Open Access Series of Imaging Studies data sets were used in this study to investigate callosal change. High-resolution structural MRI was performed in 196 older patients. Subjects were characterized using the Clinical Dementia Rating (CDR); 98 healthy controls were not demented (CDR 0), and 98 patients had clinical diagnosis of AD in the very mild dementia stage (CDR 0.5; n = 70) and the mild dementia stage (CDR 1; n = 28). A semiautomatic segmentation method was used to extract the CC in the midsagittal plane. The total and regional areas of the CC were measured. The results indicated that callosal atrophy occurred in when subjects' CDRs were 0.5. The area of the genu and rostral body of the CC in the healthy controls (CDR 0) was significantly different from that of the subjects with very mild dementia (CDR 0.5) (P < .05). A significant difference could also be found in the area of the rostral body and midbody of the CC between subjects with very mild dementia (CDR 0.5) and those with m...Continue Reading

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Citations

Jan 17, 2013·Brain Structure & Function·Babak A ArdekaniJohn J Sidtis
Jun 3, 2014·Journal of Affective Disorders·Fabienne CyprienSylvaine Artero
Jul 6, 2016·Frontiers in Cellular Neuroscience·Attila SomogyiErvin Wolf
Nov 7, 2013·Dementia and Geriatric Cognitive Disorders·Minwei ZhuZhiguo Lin
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Rui-Hua YinJin-Tai Yu
Sep 25, 2019·The International Journal of Neuroscience·Viviana Lo BuonoSilvia Marino
Aug 4, 2018·Computational and Mathematical Methods in Medicine·Wenpeng GaoMinwei Zhu
Jan 4, 2020·Brain Imaging and Behavior·Xiaoxi JiUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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