PMID: 9537851Apr 16, 1998Paper

Progression of hepatocellular carcinoma as reflected by nuclear DNA ploidy and cellular differentiation

Journal of Hepatology
T OriyamaE Okamoto

Abstract

Intratumor heterogeneity of DNA ploidy within a single hepatocellular carcinoma is not well understood. The present study was designed to examine the histologic distribution of intratumor DNA ploidy in hepatocellular carcinomas of different growth types in relation to cell differentiation. Twenty patients (16 men and four women; mean age, 60.2 years) with hepatocellular carcinoma (mean diameter, 4.3 cm) were studied. One hundred and twenty-seven samples from different sites of each tumor were analyzed by determination of the nuclear DNA content and histological examination. The DNA ploidy was heterogeneous in nine (45%) of the 20 tumors. Five tumors had a mixture of diploid and aneuploid regions, and the remaining four consisted of aneuploid regions with different DNA indices. There was no significant difference in patient characteristics between the heterogeneous and homogeneous groups. A significant correlation was found between tumor growth type and the incidence of heterogeneity. Only 16% of single nodular carcinomas without intratumor septal formation exhibited heterogeneity, while single nodular tumors with septal formation or confluent multinodular tumors were associated with high incidences of different DNA ploidy patte...Continue Reading

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Citations

Feb 20, 2007·Medical Hypotheses·Fabio Grizzi, Maurizio Chiriva-Internati
May 4, 2020·World Journal of Urology·Franziska BüscheckMichael Rink
Mar 2, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shengtao LinJianxiong Wu

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