Progression of kidney dysfunction in the community-dwelling elderly

Kidney International
B R HemmelgarnB F Culleton

Abstract

Despite the high prevalence of chronic kidney disease among the elderly, few studies have described their loss of kidney function. We sought to determine the progression of kidney dysfunction among a community-based cohort of elderly subjects. The cohort included 10 184 subjects 66 years of age or older, who had one or more outpatient serum creatinine measurements during each of two time periods: 1 July to 31 December 2001 and 1 July to 31 December 2003. A mixed effects model, including covariates for age, gender, diabetes mellitus, and comorbidity, was used to determine the rate of decline in estimated glomerular filtration rate (eGFR, in ml/min/1.73 m2) per year over a median follow-up of 2.0 years. Subjects with diabetes mellitus had the greatest decline in eGFR of 2.1 (95% CI 1.8-2.5) and 2.7 (95% CI 2.3-3.1) ml/min/1.73 m2 per year in women and men, respectively. The rate of decline for women and men without diabetes mellitus was 0.8 (95% CI 0.6-1.0) and 1.4 (95% CI 1.2-1.6) ml/min/1.73 m2 per year. Subjects with a study mean eGFR<30 ml/min/1.73 m2, both those with and without diabetes mellitus, experienced the greatest decline in eGFR. In conclusion, we found that the majority of elderly subjects have no or minimal progre...Continue Reading

References

Feb 8, 1992·BMJ : British Medical Journal·S BjörckM Aurell
Jul 22, 1989·BMJ : British Medical Journal·H H Parving, E Hommel
Aug 26, 1989·BMJ : British Medical Journal
Apr 1, 1985·Journal of the American Geriatrics Society·R D LindemanN W Shock
Aug 1, 1995·Medical Care·D O ClarkG E Simon
Jun 4, 1994·BMJ : British Medical Journal·J M Bland, D G Altman
Jun 4, 1994·BMJ : British Medical Journal·R Persaud
Apr 2, 1994·BMJ : British Medical Journal·J M Bland, D G Altman
Aug 3, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C Y HsuG C Curhan
May 1, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L DuncanA Levin
Sep 22, 2001·The New England Journal of Medicine·E J LewisUNKNOWN Collaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Nov 14, 2001·The American Journal of Medicine·A PapaioannouJ D Adachi
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hariprasad S TrivediPaulette Saab
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·Andrew G BostomEberhard Ritz
Sep 17, 2002·Annals of Internal Medicine·Kraig S KinchenNeil R Powe
Nov 21, 2002·JAMA : the Journal of the American Medical Association·Jackson T WrightUNKNOWN African American Study of Kidney Disease and Hypertension Study Group
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Feb 13, 2003·Archives of Internal Medicine·Peter J SwedkoAyub Akbari
Mar 13, 2003·Kidney International·Guruprasad ManjunathMark J Sarnak
Apr 23, 2003·Journal of the American College of Cardiology·Linda F FriedAnne B Newman
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Steven J ChadbanRobert C Atkins
Sep 16, 2003·The American Journal of Cardiology·Claudia U ChaeGary C Curhan
Oct 29, 2003·Circulation·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Nov 8, 2003·Hypertension·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Feb 19, 2004·JAMA : the Journal of the American Medical Association·Caroline S FoxDaniel Levy
Mar 11, 2004·The American Journal of Geriatric Cardiology·Michael G ShlipakAnne B Newman
Apr 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Robert JohnPaul E Stevens
Aug 31, 2004·International Journal of Epidemiology·Adrian G BarnettAnnette J Dobson
Sep 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Marc GoldsteinPhilip McFarlane
Oct 16, 2004·BMJ : British Medical Journal·Catherine M ClaseBryce A Kiberd
Dec 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bryan M CurtisAdeera Levin
Jan 22, 2005·Journal of the American Society of Nephrology : JASN·Marc FroissartPascal Houillier

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Citations

Apr 30, 2008·Archives of Internal Medicine·Lawrence J AppelUNKNOWN African American Study of Kidney Disease and Hypertension Collaborative Research Group
Jul 21, 2007·International Journal of Health Care Finance and Economics·Braden J MannsKenneth J Taub
Oct 15, 2011·International Urology and Nephrology·Pierangela PrestaGiorgio Fuiano
Dec 16, 2011·Sleep & Breathing = Schlaf & Atmung·Aibek E Mirrakhimov
Nov 2, 2011·Internal and Emergency Medicine·Filippo Mangione, Antonio Dal Canton
Sep 4, 2007·The American Journal of Medicine·Sheldon Hirsch
Jun 3, 2009·Nature Reviews. Nephrology·Chris Baylis
Jun 30, 2011·Nature Reviews. Nephrology·Adeera Levin, Paul E Stevens
Oct 1, 2011·Rejuvenation Research·Sandra V GiannelliJack Guralnik
Sep 11, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chris Baylis
Apr 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrew Innes
Mar 7, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adeera Levin
Jul 23, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paul RoderickTerry Feest
Nov 6, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rebecca HanrattyEdward P Havranek
Jun 17, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Benedicte StengelCatherine Helmer
Nov 8, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nagi AltemtamMeguid El Nahas
Jun 27, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aminu BelloUNKNOWN Alberta Kidney Disease Network
Apr 15, 2008·Current Opinion in Nephrology and Hypertension·Kellie Hunter Campbell, Ann M O'Hare
Oct 23, 2008·Current Opinion in Nephrology and Hypertension·Danilo Fliser
Mar 6, 2012·Current Opinion in Nephrology and Hypertension·Graham Abra, Manjula Kurella Tamura
Mar 23, 2013·Current Opinion in Nephrology and Hypertension·Jane O Schell, Ann M O'Hare
Jan 10, 2008·Blood Purification·Madhukar Misra
Feb 9, 2008·Nephron. Clinical Practice·Ryota IkeeShuzo Kobayashi
Apr 8, 2009·American Journal of Nephrology·Michael G ShlipakMark J Sarnak
Oct 21, 2009·BMC Nephrology·Brenda R HemmelgarnMarcello Tonelli
Apr 15, 2008·BMC Public Health·Qiu-Li Zhang, Dietrich Rothenbacher
Feb 18, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Arihiro KiyosueRyozo Nagai
May 24, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Enyu ImaiSeiichi Matsuo
May 12, 2011·PloS One·Sofia B AhmedPatrick J Hanly
Dec 19, 2013·PloS One·Lise WeisUNKNOWN NephroTest Study Group
Mar 10, 2012·Journal of the American Society of Nephrology : JASN·Tanvir Chowdhury Turin, Brenda R Hemmelgarn
Jan 31, 2014·Clinical Interventions in Aging·Robert G Fassett
Mar 12, 2008·Drugs & Aging·Ramnath DukkipatiRajnish Mehrotra
Jan 24, 2014·Current Opinion in Urology·Brian R LaneSteven C Campbell
Nov 28, 2013·European Radiology·Manal AzzouzHenrik S Thomsen
Nov 8, 2013·Clinical and Experimental Nephrology·Reiko OkuboKunihiro Yamagata

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