Progression of lower urinary tract symptoms after discontinuation of 1 medication from 2-year combined alpha-blocker and 5-alpha-reductase inhibitor therapy for benign prostatic hyperplasia in men--a randomized multicenter study

Urology
Victor Chia-Hsiang LinHann-Chorng Kuo

Abstract

To investigate the treatment outcome of discontinuing 1 medication from 2-year combination therapy for male benign prostatic hyperplasia/lower urinary tract symptoms. Patients with International Prostate Symptom Score ≥ 8, total prostatic volume (TPV) >30 mL, and maximum flow rate (Qmax) <15 mL/s were randomly assigned to the 5α-reductase inhibitor (5ARI) discontinue (DC-5ARI) or α-blocker discontinue (DC-α-blocker) group. All patients received combination therapy with dutasteride (0.5 mg QD) and doxazosin (4 mg QD) for 2 years and then discontinued either one drug for 12 months. The primary endpoint was the occurrence of resuming medication. The secondary endpoints were the net parameters changed or the need of transurethral resection of the prostate (TURP). A total of 117 patients in DC-5ARI and 113 in DC-α-blocker group completed the study. The baseline TPV and Qmax were similar between groups before combination therapy. Resumption of combination therapy was significantly more in DC-5ARI than DC-α-blocker group (51.3% vs 31.0%; P = .005). The mean duration from discontinuing to resuming medication was 5.0 ± 4.4 months in DC-α-blocker and 7.8 ± 3.8 months in DC-5ARI group (P <.05). The TPV progression (29.1% vs 8.0%; P <.001)...Continue Reading

Citations

Apr 15, 2016·British Journal of Clinical Pharmacology·Amy T PageChristopher D Etherton-Beer
Jul 28, 2016·Maturitas·Amy Theresa PageChristopher Etherton-Beer
Aug 22, 2014·Current Opinion in Urology·Karl-Erik Andersson
Jan 20, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Teppei MatsumotoChikara Ohyama
Sep 27, 2018·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Sioe Lie ThioJeanet W Blom
Feb 29, 2020·Ci Ji Yi Xue Za Zhi = Tzu-chi Medical Journal·Jing-Liang ChenHann-Chorng Kuo

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