PMID: 25738363Mar 5, 2015Paper

Progression of naive intraepithelial neoplasia genome to aggressive squamous cell carcinoma genome of uterine cervix

Oncotarget
Seung-Hyun JungYeun-Jun Chung

Abstract

Although cervical intraepithelial neoplasia (CIN) is considered a neoplasia, its genomic alterations remain unknown. For this, we performed whole-exome sequencing and copy number profiling of three CINs, a microinvasive carcinoma (MIC) and four cervical squamous cell carcinomas (CSCC). Both total mutation and driver mutation numbers of the CINs were significantly fewer than those of the MIC/CSCCs (P = 0.036 and P = 0.018, respectively). Importantly, PIK3CA was altered in all MIC/CSCCs by either mutation or amplification, but not in CINs. The CINs harbored significantly lower numbers of copy number alterations (CNAs) than the MIC/CSCCs as well (P = 0.036). Pathway analysis predicted that the MIC/CSCCs were enriched with cancer-related signalings such as cell adhesion, mTOR signaling pathway and cell migration that were depleted in the CINs. The mutation-based estimation of evolutionary ages identified that CIN genomes were younger than MIC/CSCC genomes. The data indicate that CIN genomes harbor unfixed mutations in addition to human papilloma virus infection but require additional driver hits such as PIK3CA, TP53, STK11 and MAPK1 mutations for CSCC progression. Taken together, our data may explain the long latency from CIN to CS...Continue Reading

Associated Datasets

References

Nov 10, 1998·Virchows Archiv : an International Journal of Pathology·J Y LeeW S Park
Jun 5, 2002·Nature Reviews. Cancer·Harald zur Hausen
Mar 3, 2004·Nature Reviews. Cancer·P Andrew FutrealMichael R Stratton
Nov 16, 2005·International Journal of Cancer. Journal International Du Cancer·Bjørn I BertelsenOle Didrik Laerum
Dec 23, 2006·Nature Reviews. Cancer·Ciaran B J WoodmanLawrence S Young
Aug 7, 2007·Nature·Hongbin JiKwok-Kin Wong
Feb 13, 2008·Journal of the National Comprehensive Cancer Network : JNCCN·Heidi J Gray
Mar 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Siân JonesSanford D Markowitz
Apr 3, 2008·The Surgical Clinics of North America·Bradford P Whitcomb
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jul 6, 2010·Nucleic Acids Research·Kai WangHakon Hakonarson
Oct 29, 2010·Nature·Shinichi YachidaChristine A Iacobuzio-Donahue
Jun 4, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Cara M Martin, John J O'Leary
Jan 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Filip JankuRazelle Kurzrock
Aug 24, 2012·Bioinformatics·Fernando García-AlcaldeAna Conesa
Sep 14, 2012·Nature Reviews. Cancer·Josep V FormentStephen P Jackson
Oct 2, 2012·International Journal of Oncology·Eun Kyeong OhWoong Shick Ahn
Feb 12, 2013·Nature Biotechnology·Kristian CibulskisGad Getz
Sep 24, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lorenz K ThomasMiriam Reuschenbach
Jan 7, 2014·Nature·Akinyemi I OjesinaMatthew Meyerson
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xiaohong WangZhi-Ming Zheng
May 30, 2014·The Journal of Pathology·Tae-Min KimSug-Hyung Lee

❮ Previous
Next ❯

Citations

Aug 18, 2017·Proteomics. Clinical Applications·Jingjing ZhangYadong Feng
Feb 10, 2018·Experimental & Molecular Medicine·Mi-Ryung HanYeun-Jun Chung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.