Progression of native lung fibrosis in lung transplant recipients with idiopathic pulmonary fibrosis

Respiratory Medicine
Brett ElickerSteven R Hays

Abstract

Single lung transplant recipients with idiopathic pulmonary fibrosis provide an opportunity to study fibrosis in the native lung over time in the setting of pronounced immunosuppression. Lung transplant patients are treated with a regimen of steroids, an antiproliferative agent and a calcineurin inhibitor. This represents a much greater immunosuppression regime than the typical treatment for IPF. To determine whether this regimen of high dose immunosuppression would arrest the progression of fibrosis, the high-resolution chest CT scans (HRCTs) of these patients were reviewed. HRCTs of 21 patients who underwent single lung transplant for IPF between 1/96 and 1/06 were reviewed. Scans were evaluated by two readers at 6 months intervals, beginning within 1-2 months after transplant. Two calculations were made on the native lung: total volume and percentage of lung affected by fibrosis. Baseline pulmonary function test data was correlated with the immediate post-transplant CT. Patients were followed for an average of 35 months after transplant. The mean total volume of the native lung just after transplant was 1120cc. This decreased to 875cc by 2 years and 691cc by 4 years after transplant, representing an average decline of 10.8%/...Continue Reading

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Citations

Mar 31, 2015·Journal of Autoimmunity·Shulamit B Wallach-DayanRaphael Breuer
Mar 30, 2016·Chest·Anna Serrano-MollarUNKNOWN Pneumocyte Study Group
Sep 24, 2015·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Adalberto Sperb RubinJosé Jesus Camargo
Jun 16, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Brett M ElickerTravis S Henry
Apr 26, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Marco E AllaixMarco G Patti

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