Progression of pancreatic morphology in chronic pancreatitis is not associated with changes in quality of life and pain.

Scandinavian Journal of Gastroenterology
Emilie SteinkohlJens Brøndum Frøkjær

Abstract

In patients with chronic pancreatitis (CP), the aim was to explore the association between pancreatic morphological progression over four years and corresponding changes in disease characteristics, including quality of life (QOL), pain, and exocrine pancreatic function. Twenty-five patients with CP were followed by magnetic resonance imaging (MRI). Data were obtained at baseline and after 4-year follow-up, including clinical information, QOL, and pain as assessed by validated questionnaires. Morphological assessments were derived from the same MRI scanner and included pancreatic gland volume, apparent diffusion coefficient values, fat signal fraction, and main pancreatic duct diameter. After four years, CP patients showed significant progression in morphological parameters of the pancreas, except for the ductal-related changes (p < .13). Hence, patients developed reduced pancreatic volume by 13.5% (p < .001), an increase of fibrosis by 10.8% (p < .001), and an increase of fat infiltration by 7.6% (p < .001). In contrast, the patient-reported outcomes of QOL and pain did not change significantly over four years (all p > .05). Moreover, the progression of morphological imaging findings was not related to changes in QOL, pain seve...Continue Reading

References

Jun 1, 1980·The British Journal of Surgery·P C BornmanJ P Wright
Jul 23, 1998·Journal of Clinical Epidemiology·K C SneeuwJ H Schornagel
Jan 19, 2000·The American Journal of Gastroenterology·N A KoloskiP M Boyce
May 31, 2001·European Journal of Clinical Investigation·J Walkowiak, K H Herzig
Nov 19, 2003·Scandinavian Journal of Gastroenterology·M WehlerT Schneider
Mar 24, 2005·The American Journal of Gastroenterology·Deborah FitzsimmonsColin D Johnson
Jul 30, 2005·European Journal of Pain : EJP·Tito MendozaCharles Cleeland
Sep 4, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·David C WhitcombUNKNOWN North American Pancreatic Study Group
Jun 10, 2009·Archives of Internal Medicine·Dhiraj YadavUNKNOWN North American Pancreatic Study Group
Jul 16, 2009·The American Journal of Gastroenterology·Paul Georg LankischPatrick Maisonneuve
Feb 2, 2011·Pancreas·Marie-France PhilippeEtienne Larger
Mar 15, 2011·Lancet·Joan M BraganzaMichael J McMahon
Oct 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Anna MokrowieckaEwa Małecka-Panas
Nov 22, 2013·World Journal of Gastroenterology : WJG·Jakob Lykke PoulsenAsbjørn Mohr Drewes
Nov 27, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·C Mel WilcoxMichelle A Anderson
Feb 7, 2017·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Adnan MadzakJens Brøndum Frøkjær
Sep 1, 2017·European Journal of Gastroenterology & Hepatology·Adnan MadzakJens Brøndum Frøkjær
Nov 3, 2017·World Journal of Gastroenterology : WJG·Vikesh K SinghPedro M Quintana Diez
Nov 7, 2017·European Journal of Pain : EJP·L Arendt-NielsenA Mohr Drewes
Sep 5, 2018·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jens Brøndum FrøkjærUNKNOWN Working group for the International (IAP – APA – JPS – EPC) Consensus Guidelines for Chronic Pancreatitis
Oct 17, 2018·Radiology·Temel TirkesUNKNOWN Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
Jan 8, 2020·Nature Reviews. Disease Primers·Asbjørn M DrewesSøren S Olesen
Feb 20, 2020·European Journal of Radiology·Emilie SteinkohlJens Brøndum Frøkjær

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