Progression of Parkinson's disease following thalamic deep brain stimulation for tremor

Stereotactic and Functional Neurosurgery
Daniel TarsyThorkild Norregaard

Abstract

We assessed the long-term effect of thalamic deep brain stimulation (DBS) on motor symptoms and progression of Parkinson's disease (PD) in PD patients treated for resting and postural/action tremor. Thalamic DBS was performed in 17 patients with treatment-resistant resting and postural/action tremor. Nine patients were available for follow-up examination a mean of 5.5 years after surgery. Three had tremor-dominant PD. DBS produced marked improvement in resting and postural/action tremor in target upper extremity in all 9 patients, which persisted unchanged at the time of the last follow-up visit 5.5 years after surgery. PD severity with DBS 'on' and 'off' 1 year after surgery was compared to PD severity at the last follow-up visit using UPDRS (Unified Parkinson's Disease Rating Scale) III motor scores and individual motor item subscores. Patients were tested while on medication. There was no significant worsening of tremor, rigidity, speech, postural stability, gait, or axial bradykinesia with DBS either on or off at the last follow-up visit compared to the 12-month visit. UPDRS III motor scores were unchanged. However, global assessment of PD progression and increased mean L-dopa dose and L-dopa equivalent daily dose at the ti...Continue Reading

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Citations

Aug 29, 2014·Surgical Neurology International·Damián BenderskyClaudio Yampolsky
Dec 5, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Maria C Rodriguez-OrozPaul Krack
Mar 2, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Wen-Han HuJian-Guo Zhang
Jan 27, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Soha AlomarAndres M Lozano
Jan 27, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Paul KrackJose A Obeso

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