Progression of periodontal destruction and the roles of advanced glycation end products in experimental diabetes

Journal of Periodontology
Po-Chun ChangKok Yong Erk

Abstract

Progression of diabetes-associated periodontal destruction and the roles of advanced glycation end products (AGEs) are investigated. Diabetes was induced by streptozocotin injection, and periodontitis was induced via silk ligature placement with Porphyromonas gingivalis lipopolysaccharide injection in 64 Sprague-Dawley rats for 7 to 21 days. The quality of alveolar bone and attachment loss (AL) were measured by microcomputed tomography and histology. Destruction profiles were evaluated by histology, histochemistry, immunohistochemistry, and quantitative assessments of inflammatory cells, expression of receptors for AGEs (RAGE), tartrate-resistant acid phosphatase, and proliferating cell nuclear antigen. Without periodontitis induction, there was no obvious morphologic change in the periodontium, although slight elevations of AGEs and RAGE levels were noted in animals with diabetes. In the group with experimental periodontitis, significant periodontal bone loss was noted in animals both with and without diabetes from day 7, with more progressive bone loss in animals with diabetes during days 14 to 21. Histologically, the disruption of attachment and inflammation were observed from day 7, but subsequently subsided in animals with...Continue Reading

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Citations

Aug 13, 2013·Lasers in Medical Science·Po-Chun ChangLi Yen Chong
Feb 19, 2016·Journal of Periodontology·Min-Chen YuPo-Chun Chang
Jan 7, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Sheng-Chueh TsaiPo-Chun Chang
Aug 8, 2015·Periodontology 2000·Sarah K Sonnenschein, Joerg Meyle
Dec 3, 2014·Journal of the Neurological Sciences·Chandramohan Wakade, Raymond Chong
Mar 28, 2017·Journal of Clinical Periodontology·Alberto MonjeWenche S Borgnakke
Feb 21, 2014·Journal of Dental Research·P-C ChangC-C Chen
Mar 4, 2018·Journal of Clinical Periodontology·Daniela Pereira CatanzaroGerson Francisco Assis
Jan 20, 2018·Clinical Implant Dentistry and Related Research·Zeyad H Al-SowyghZohaib Akram
Jul 12, 2018·Brazilian Oral Research·Saeed Al Zahrani, Abdullah Abdulaziz Al Mutairi
Mar 19, 2016·Oncotarget·Sandeep Vasant More, Dong-Kug Choi
Oct 24, 2013·BioMed Research International·Rayyan A Kayal
Sep 16, 2017·Journal of Periodontology·Nara L T NunesFlávia A C Furlaneto
Aug 9, 2018·Brazilian Oral Research·Mohammed AlasqahFawad Javed
Feb 19, 2019·Journal of Dental Research, Dental Clinics, Dental Prospects·Arati C KoregolPriya Sinha

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