Progression of Rebound-Associated Vertebral Fractures Following Denosumab Discontinuation Despite Reinstitution of Treatment: Suppressing Increased Bone Turnover May Not Be Enough.

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
A D AnastasilakisSymeon Tournis

Abstract

Rebound-associated vertebral fractures (RAVFs) could occur in a minority of the patients who discontinue denosumab. In such patients, denosumab is often reinstituted to rapidly suppress bone turnover and avert the risk of additional fractures. Herein we report the cases of 2 patients who sustained RAVFs, and in whom resuming denosumab treatment did not avert the occurrence of new RAVFs a few months later, despite the suppression of bone turnover markers. It seems that denosumab reinstitution cannot completely eliminate the risk of new RAVFs and that the rebound of bone turnover may not be the sole mechanism to explain this phenomenon.

References

Jun 5, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pirow J BekkerAlex M DePaoli
Feb 28, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Athanasios D AnastasilakisOlivier Lamy
Nov 7, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven R CummingsJacques P Brown
Apr 25, 2018·European Journal of Endocrinology·Athanasios D AnastasilakisPolyzois Makras
Jan 4, 2020·Archives of Osteoporosis·Rui NiimiAkihiro Sudo
Jul 28, 2020·Annals of Internal Medicine·Kristine E Ensrud, John T Schousboe

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Citations

Jan 8, 2021·Journal of Clinical Medicine·Athanasios D AnastasilakisAndrea Palermo
Feb 6, 2021·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Athanasios D AnastasilakisSymeon Tournis

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