PMID: 9184449May 1, 1997Paper

Progression of renal disease in patients with reflux nephropathy. Follow-up study

Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
Y NakashimaK Sakamoto

Abstract

We previously estimated the turning point of reflux nephropathy irreversibly deteriorating to end stage renal disease, mainly based on findings in renal biopsy (Eur. Urol., 26: 153-159, 1994). In this study, we aim to evaluate clinical parameters which may be closely associated with progression of reflux nephropathy to end stage renal disease. Ninety five patients (84 children and 11 adults; 41 men and 54 women) with renal scar and/or reflux (>/ = grade 3), mean aged 9.4 +/- 9.1 years (3 months-53 years) were followed up for 3.7 years +/- 2.7 (6 months-18 years). Vesicoureteral reflux was bilateral in 64 and unilateral in 31; primary in 85 and secondary in 10 patients. Clinical parameters including body weight, height, blood pressure, 24 hour urinary protein excretion, serum creatinine, 99m Tc-DTPA GFR and 99 m Tc-DMSA uptake were monitored over time. All patients underwent antireflux surgery (with or without other reconstructive surgery) and open renal biopsy. Three patients progressing to end stage renal disease underwent subsequent biopsy. Over-5 year observation period, the prevalence of new scare formation and further extension in scar was significantly higher in the group of renal functional deterioration (35%) than in th...Continue Reading

Citations

Feb 5, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guy H Neild
Oct 7, 2004·BMC Nephrology·Guy H NeildChristopher R J Woodhouse
May 4, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Fatima TokhmafshanIndra R Gupta
Apr 3, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Hideshi MiyakitaMasayuki Kubota

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