Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons

The European Journal of Neuroscience
Jan A GorterFernando H Lopes da Silva

Abstract

The development of spontaneous limbic seizures was investigated in a rat model in which electrical tetanic stimulation of the angular bundle was applied for up to 90 min. This stimulation produced behavioural and electrographic seizures that led to a status epilepticus (SE) in most rats (71%). Long-term EEG monitoring showed that the majority of the rats (67%) that underwent SE, displayed a progressive increase of seizure activity once the first seizure was recorded after a latent period of about 1 week. The other SE rats (33%) did not show this progression of seizure activity. We investigated whether these different patterns of evolution of spontaneous seizures could be related to differences in cellular or structural changes in the hippocampus. This was the case regarding the following changes. (i) Cell loss in the hilar region: in progressive SE rats this was extensive and bilateral whereas in nonprogressive SE rats it was mainly unilateral. (ii) Parvalbumin and somatostatin-immunoreactive neurons: in the hilar region these were almost completely eliminated in progressive SE rats but were still largely present unilaterally in nonprogressive SE rats. (iii) Mossy fibre sprouting: in progressive SE rats, extensive mossy fibre s...Continue Reading

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Citations

Jun 25, 2003·Experimental Neurology·Karin BorgesRaymond Dingledine
Feb 20, 2002·Trends in Neurosciences·Annad d H RatzliffIvan Soltesz
Jan 25, 2003·The European Journal of Neuroscience·Katarzyna LukasiukAsla Pitkänen
Jun 16, 2007·Epilepsia·Edward Bertram
Feb 13, 2008·Epilepsia·Erwin A van VlietJan A Gorter
May 15, 2012·Epilepsia·Aristea S GalanopoulouCarlos Cepeda
Oct 15, 2009·Epilepsy Currents·Michael Wong
Sep 19, 2008·Journal of Neurophysiology·Erika E FanselowBarry W Connors

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