Progression of vertebral fractures in long-term controlled acromegaly: a 9-year follow-up study

European Journal of Endocrinology
I C M PelsmaK M J A Claessen

Abstract

Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) excess results in both reversible and irreversible musculoskeletal damage, including increased vertebral fracture (VF) risk. The prevalence of VFs is approximately 60% in controlled acromegaly patients, and these VFs can progress in time. We aimed to identify the course of VFs in a cohort of acromegaly patients in long-term remission and their associated risk factors during prolonged follow-up. Thirty-one patients with acromegaly (49% female, median age 60 years (IQR 53-66)), who were in remission for ≥2 years, were included in this longitudinal, prospective, follow-up study. Spine radiographs of vertebrae Th4 to L4 were assessed for VFs using the Genant score, at baseline, after 2.6 years and 9.1 years. Progression was defined as either a new fracture or a ≥1-point increase in Genant score. The prevalence of VF at baseline was 87% (27/31 patients). Progression of VFs was observed in eleven patients (35.5%) during the 9.1-year follow-up period, with a total incidence rate of 65.5 per 1000 person years (males 59.8 per 1000 person years vs females 71.6 per 1000 person years). Patients treated with surgery or radiotherapy had a higher risk of VF progression in this cohor...Continue Reading

Citations

Oct 21, 2020·Pituitary·Maria FleseriuShlomo Melmed
Oct 26, 2020·The Journal of Clinical Endocrinology and Metabolism·Iris C M PelsmaKim M J A Claessen
Feb 20, 2021·Hormones : International Journal of Endocrinology and Metabolism·Flaminia CarroneGherardo Mazziotti
Apr 4, 2021·Journal of Clinical Medicine·Jill Sisco, A J van der Lely
Jun 9, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Adriana G Ioachimescu
Apr 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Paula P B SilvaRaquel S Jallad
Aug 28, 2021·Endocrine·Kim M J A ClaessenNatasha M Appelman-Dijkstra
Jul 17, 2021·The Journal of Clinical Endocrinology and Metabolism·Martin KužmaJuraj Payer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.