Progression to cirrhosis in Latinos with chronic hepatitis C: differences in Puerto Ricans with and without human immunodeficiency virus coinfection and along gender

Journal of Clinical Gastroenterology
Maribel Rodríguez-TorresNorbert Bräu

Abstract

Hepatitis C virus (HCV) infection is prevalent in Latinos. There is some evidence that progression to cirrhosis is more rapid. To calculate time of cirrhosis from time of HCV infection in a large Latino population. Other end points were to assess variables that predict cirrhosis and the effect of gender, alcohol, and human immunodeficiency virus (HIV) infection status on time to cirrhosis. Four hundred sixty-nine Latino patients evaluated at a referral center in Puerto Rico were included. Several demographic parameters, such as risk factors, estimated duration of HCV infection, alcohol use, HIV status, and findings from the usual HCV and HIV laboratory tests were noted. All patients had liver biopsy specimens assessed by Ishak score. Monoinfected and coinfected latinos have a median cumulative risk/hazard for cirrhosis of 42.0 vs. 32.0 years after infection (P = 0.0016). The median age of cirrhotic patients is 53.0 years in monoinfections and 42.0 years in coinfection. Among coinfected patients there is no gender-associated difference in time to onset of cirrhosis (P = 0.785). Among monoinfected patients, males have a shorter median risk/hazard to cirrhosis than females (11.0-year difference; P = 0.05) and have a shorter time u...Continue Reading

References

Nov 1, 1992·Journal of Hepatology·F TremoladaG Realdi
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M Di BisceglieH J Alter
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jun 1, 1995·The New England Journal of Medicine·M J TongR L Co
Jun 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YanoK Okuda
Jan 1, 1997·Journal of Hepatology·S Erlinger
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T E WileyT J Layden
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C NiederauD Häussinger
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L MasonR P Perrillo
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D M Bissell
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L F HouriganE E Powell
Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BenhamouT Poynard
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C L ThioM Carrington
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E E PowellJ R Jonsson
Jul 25, 2000·JAMA : the Journal of the American Medical Association·D L ThomasD Vlahov
Aug 18, 2000·Seminars in Liver Disease·P A Sheiner
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MezawaY Niitsu
Jul 7, 2001·The New England Journal of Medicine·G M Lauer, B D Walker
Aug 22, 2001·The American Journal of Gastroenterology·M BonaciniK L Lindsay
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J FreemanJ M Kaldor
Dec 4, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V Di MartinoP Marcellin
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Apr 2, 2002·The American Journal of Gastroenterology·Damien B Mallat, Lennox Jeffers
May 2, 2002·Journal of Gastroenterology and Hepatology·Gregory J DoreJohn M Kaldor
May 23, 2002·Gastroenterology·Jeanne M ClarkAnna Mae Diehl
Feb 15, 2003·Journal of Hepatology·Thierry PoynardUNKNOWN PANFIBROSIS Group
Feb 19, 2003·Journal of Clinical Gastroenterology·Renuka Bhattacharya, Margaret C Shuhart
Apr 3, 2003·The Journal of Clinical Hypertension·Sean O HendersonBrian E Henderson
Jun 26, 2003·Journal of Viral Hepatitis·A J FreemanG J Dore
Oct 18, 2003·Journal of Clinical Gastroenterology·Anne M LarsonKris V Kowdley

❮ Previous
Next ❯

Citations

Jan 16, 2009·The New England Journal of Medicine·Maribel Rodriguez-TorresUNKNOWN Latino Study Group
Aug 13, 2009·World Journal of Gastroenterology : WJG·Ashwani-K Singal, Bhupinderjit S Anand
Dec 1, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Sumiko Nagoshi
Sep 27, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sabra L Klein
Aug 25, 2015·The International Journal on Drug Policy·Daniel J SmithHolly Hagan
May 10, 2015·Infection·Julia FischerClara Lehmann
Sep 1, 2009·Therapeutic Advances in Gastroenterology·Udayakumar NavaneethanGuy W Neff
Apr 15, 2010·The American Journal of Gastroenterology·Luis A BalartUNKNOWN LATINO study investigators
Mar 23, 2017·World Journal of Hepatology·Neeta K VenepalliScott J Cotler
Sep 16, 2011·Current Opinion in HIV and AIDS·Ponsiano Ocama, Emmanuel Seremba

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.