Progressive alcohol-induced sperm alterations leading to spermatogenic arrest, which was reversed after alcohol withdrawal

Reproductive Biomedicine Online
Nathalie SermondadeJacqueline Mandelbaum

Abstract

This is a report of a 6-year follow-up of a male patient's semen parameters during heavy chronic alcohol intoxication and after withdrawal. A slowly progressive negative impact of alcohol could be observed: isolated moderate teratozoospermia was firstly noted followed by oligoasthenoteratospermia. Then a severe worsening resulted in cryptozoospermia and ultimately in azoospermia. At this moment, the histological analysis of a testicular biopsy revealed a maturation arrest of the germinal cells at the pachytene stage with no mature sperm cells. Alcohol withdrawal was then obtained, allowing a very fast and drastic improvement of semen characteristics; strictly normal semen parameters were observed after no more than 3 months. Taking into consideration these data, patients should be questioned about their alcohol intake before assisted reproductive technology and should be informed about this adverse effect. Moreover, this case report emphasizes how quickly benefits can be obtained after withdrawal, even in the case of heavy chronic alcohol intake.

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Citations

Nov 20, 2012·Journal of Human Reproductive Sciences·Dilip Gude
Jun 15, 2014·Reproductive Biomedicine Online·Sergey L YaroshAlexey V Polonikov
Aug 24, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Bruno GuthauserFrancois Vialard
Dec 27, 2011·Reproductive Biomedicine Online·Nathalie SermondadeRachel Lévy
Mar 10, 2016·Asian Journal of Andrology·David F Yao, Jesse N Mills
Sep 29, 2017·European Journal of Drug Metabolism and Pharmacokinetics·Oluwatosin O OgedengbeOnyemaechi O Azu
Sep 12, 2014·Clinical Medicine Insights. Reproductive Health·Gleice Cristina Dos Santos GodoySebastião Freitas de Medeiros
May 28, 2019·Journal of Clinical Medicine·Ylenia DucaSandro La Vignera
Jan 1, 2013·Asian Journal of Andrology·Sandro La VigneraAldo E Calogero
Apr 25, 2020·Andrologia·Kristian Leisegang, Sulagna Dutta
Jul 31, 2021·Journal of Assisted Reproduction and Genetics·Nicolás RamírezAna Carolina Martini

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