PMID: 8596380Mar 9, 1996Paper

Progressive cellular dehydration and proteolysis in critically ill patients

Lancet
P J FinnG L Hill

Abstract

According to a recent hypothesis, the profound loss of body protein that occurs in critically ill patients is triggered and maintained by cell shrinkage secondary to cellular dehydration. We tested this hypothesis by studying sequential changes in intracellular water, total body protein, total body potassium, and intracellular potassium in patients receiving intensive care for blunt trauma or sepsis. Nine patients with multiple blunt trauma and 11 with severe sepsis were studied in an intensive care unit for 21 days. Intracellular water was measured in two ways--by subtraction of extracellular water (bromide dilution) from total body water (tritium dilution), and by bioimpedance spectroscopy. Total body protein was measured by whole-body neutron activation analysis and total body potassium by whole-body counting. Over the study period intracellular water decreased by 15-20%, total body protein by 15%, and total body potassium by about 20%. Intracellular potassium concentration did not change, and was similar to that in healthy adult volunteers. In the trauma patients, sequential measurements of the ratio of potassium to protein in lost tissue indicated that cells were losing water in quantities greater than would be expected fr...Continue Reading

References

Jun 1, 1975·Annals of Surgery·E Lindstedt, P Sandblom
May 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·G L Hill
Jun 1, 1992·Critical Care Medicine·R C BoneW J Sibbald
May 8, 1991·European Journal of Biochemistry·C HallbruckerD Häussinger
Sep 1, 1988·The Australian and New Zealand Journal of Surgery·J A Windsor, G L Hill
Jul 1, 1985·Metabolism: Clinical and Experimental·S J StreatG L Hill

❮ Previous
Next ❯

Citations

Jul 8, 2010·International Journal of Emergency Medicine·Nik Hisamuddin Nik Ab Rahman, Ahmad Hashim
Aug 15, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·Daniel H LibratyAlan L Rothman
Jun 1, 1996·Nutrition·R D Griffiths
Oct 1, 1996·Baillière's Clinical Endocrinology and Metabolism·J WernermanP Essén
May 9, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jens Møller
Aug 6, 1998·The British Journal of Surgery·A G Hill, G L Hill
May 25, 2002·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·Karin BarendregtP B Soeters
Jan 12, 2002·Kidney International·Jonathan HimmelfarbT Alp Ikizler
May 31, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·P Ritz, UNKNOWN Source Study
May 31, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·P Ritz, UNKNOWN Investigators of the Source Study and of the Human Nutrition Research Centre-Auvergne
Jul 19, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Johan MårtenssonMax Bell
Mar 17, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·N I PatonG E Griffin
Jan 11, 2005·The Journal of Burn Care & Rehabilitation·Kathy PrelackJoseph J Kehayias
Feb 6, 2010·Critical Care Medicine·Adam LightfootRichard D Griffiths
Jan 14, 2004·Kidney International·T Alp IkizlerUNKNOWN PICARD Study Group
Jan 14, 2004·Seminars in Dialysis·Valerie A Luyckx, Joseph V Bonventre
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·I R DoyleA D Bersten
Jun 5, 2002·American Journal of Respiratory and Critical Care Medicine·Kate G DavidsonIan R Doyle
Aug 12, 2009·Critical Care : the Official Journal of the Critical Care Forum·Alex D TruongDale M Needham
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Yves Ingenbleek, Vernon R Young
Apr 27, 2010·World Journal of Gastroenterology : WJG·Branka F FilipovićNela Sibalić
Jun 17, 2009·Current Opinion in Gastroenterology·Dominic N Reeds
Sep 26, 2001·Current Opinion in Critical Care·C H DejongP B Soeters
Mar 19, 1999·Clinical and Experimental Pharmacology & Physiology·I R DoyleA D Bersten
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Arny A FerrandoRobert R Wolfe
Jan 5, 2011·Critical Care Medicine·Bala VenkateshJeremy Cohen
Sep 10, 2003·Orthopaedic Nursing·Sharon G Childs
Jul 16, 2004·Kidney International·Salvatore Di FilippoFrancesco Locatelli
Jul 30, 2009·AACN Advanced Critical Care·Eddy FanDale M Needham
Jul 1, 1997·Metabolism: Clinical and Experimental·L GamrinJ Wernerman
Aug 28, 2004·The Nursing Clinics of North America·Diane J Mick, Michael H Ackerman
Jan 12, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P V Carroll
May 1, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F Bozzetti
Mar 4, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A SchwenkL Ward
Mar 12, 2008·Expert Review of Medical Devices·James R Matthie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.