Progressive Changes in the Retinal Structure of Patients with Parkinson's Disease

Journal of Parkinson's Disease
Li-Jing MaChun-Feng Liu

Abstract

Many optical coherence tomography (OCT) studies have reported alterations in the retinal nerve fiber layer (RNFL) in Parkinson's disease (PD) and other neurodegenerative diseases. However, whether retinal alterations are a biomarker for PD is still controversial. To investigate potential correlations between PD and morphological changes in retina using OCT and to determine its usefulness as a biomarker of disease progression in PD. We performed a cross-sectional study on patients with PD (N = 37) and age-matched controls (N = 42), followed by a longitudinal study of the PD patients (N = 22) over approximately 2.5 years. The average retinal nerve fiber layer (RNFL) thickness (p < 0.001), total macular thickness (p = 0.001), and macular volume (p = 0.001) were decreased in PD patients compared to controls and had further decreased at the follow-up visit (p < 0.05 for all). The average RNFL thickness and the total thickness of macular were negatively correlated with age in PD patients at baseline. Linear regression analysis revealed that age (p = 0.002, p = 0.003, respectively) and LEDD (p = 0.011, p = 0.013, respectively) were correlated to total thickness and volume of macular in 22 PD patients in the follow-up study. However, n...Continue Reading

References

Jan 1, 1989·Ophthalmology·M X Repka, H A Quigley
Apr 14, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·C BolgerJ F Malone
Aug 8, 2002·Archives of Neurology·Ivan Bodis-Wollner
Sep 19, 2003·Neurologic Clinics·Gregory R Jackson, Cynthia Owsley
Apr 24, 2004·Documenta Ophthalmologica. Advances in Ophthalmology·Paul Witkovsky
Sep 3, 2004·Vision Research·Rivka InzelbergAvinoam Ophir
Feb 21, 2006·Lancet Neurology·K Ray ChaudhuriUNKNOWN National Institute for Clinical Excellence
Oct 27, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Ozgül AltintaşYusuf Cağlar
Jun 10, 2009·Archives of Ophthalmology·Mohammedyusuf E HajeeIvan G Bodis-Wollner
Jun 16, 2009·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Jessica M NeuvilleAnthony J Adams
Apr 27, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Amitha DomalpallyRonald P Danis
Jul 6, 2010·European Journal of Ophthalmology·Marilita M MoschosChrysanthi Koutsandrea
Apr 2, 2011·Parkinsonism & Related Disorders·N K ArchibaldD J Burn
Jul 15, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzBichun Ouyang
Mar 23, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C La MorgiaV Carelli
Jun 5, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mohammad RohaniGholamali Shahidi
Aug 18, 2012·Journal of Ophthalmology·Eric M ShrierIvan Bodis-Wollner
Oct 27, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Serkan KirbasMustafa Durmus
Dec 25, 2012·Journal of Neural Transmission·B SpundI Bodis-Wollner
Nov 28, 2013·The British Journal of Ophthalmology·M SatueE Garcia-Martin
Jan 25, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Beatriz JiménezJavier López del Val
May 3, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Nicolas M RothFriedemann Paul
Jul 24, 2014·Investigative Ophthalmology & Visual Science·Nimesh B PatelRonald S Harwerth
Aug 25, 2015·Parkinsonism & Related Disorders·Pooja MailankodyPramod Kumar Pal
Nov 20, 2016·Medicine·Jae Yon WonYoung-Hoon Park

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Citations

May 29, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Ane Murueta-GoyenaIñigo Gabilondo
Jan 23, 2020·Acta neurologica Belgica·Subramaniam Mohana DeviVellingiri Balachandar
Oct 25, 2020·Annals of Neurology·Ane Murueta-GoyenaIñigo Gabilondo
Oct 28, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Wen-Chuan ZhouJing Li

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