Progressive cognitive impairment evolving to dementia parallels parieto-occipital and temporal enlargement in idiopathic chronic hydrocephalus: a retrospective cohort study

Frontiers in Neurology
Paolo Missori, Antonio Currà

Abstract

Little is known regarding progressive enlargement of the ventricular system in symptomatic patients or asymptomatic subjects. Before eventual surgical treatment, we evaluated the clinical and radiological features of an extremely rare group of patients with idiopathic chronic hydrocephalus (ICH) and cognitive impairment evolving to dementia (n = 11), and an extremely rare group of asymptomatic or minimally symptomatic adults (AMSA) with ventricular enlargement (n = 10). We quantified changes over time in the ventricular frontal, occipital, and temporal horns by measuring the Evans' index plus a parieto-occipital ratio and a temporal ratio, and their percentage of progression. Cerebral ventricles expanded over very long term in both demented patients with ICH and in AMSA. In AMSA, frontal enlargement predominated, whereas demented patients showed predominant parieto-occipital (p = 0.00) and temporal (p = 0.00) enlargement that progressed faster than in AMSA (p = 0.00). In ICH, progression of cognitive impairment parallels ventricular parieto-occipital and temporal horn enlargement. Limitations of this study are the retrospective nature, the non-uniform use of neuropsychological tests, the reduced sample size due to the extremely...Continue Reading

References

Jun 1, 1978·Experimental Neurology·G A RosenbergR Katzman
Mar 1, 1976·Journal of Neurology, Neurosurgery, and Psychiatry·J GawlerJ Marshall
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1987·AJR. American Journal of Roentgenology·J L ShermanB J Bowen
Mar 1, 1985·Neurology·R C PetersenE R Laws
Dec 1, 1996·Journal of Neurosurgery·E R Cardoso, R Schubert
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·Petra Margarete KlingeThomas Brinker
Jul 15, 1965·The New England Journal of Medicine·R D ADAMSW H SWEET
Mar 23, 2004·Brain : a Journal of Neurology·Shahan MomjianJohn D Pickard
Apr 28, 2004·Brain : a Journal of Neurology·Gerald D Silverberg
May 7, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Brian K OwlerJohn D Pickard
Sep 15, 2005·Neurosurgery·Norman RelkinPeter McL Black
Feb 9, 2006·Acta Neurochirurgica. Supplement·U Meier, S Mutze
Jan 22, 2008·Acta Neurologica Scandinavica·A Brean, P K Eide
May 9, 2008·Neurologia Medico-chirurgica·Masatsune IshikawaHiroshi Koyama
Aug 19, 2011·Neurology·Bryan T Klassen, J Eric Ahlskog
Aug 19, 2011·Neurology·Douglas W Scharre

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