Progressive cortical reorganisation: A framework for investigating structural changes in schizophrenia

Neuroscience and Biobehavioral Reviews
Lena Palaniyappan

Abstract

One of the few well-replicated features of schizophrenia is the demonstration of neuroanatomical abnormalities affecting cortical and subcortical grey matter (GM). Evidence to date suggests that the greatest reduction in GM occurs in the immediate post-onset phase. The predominant view to date is that the accelerated grey matter (GM) loss represents an adverse process (degenerative or developmental deficit) contributing to the unfavourable course of schizophrenia. This prevailing emphasis on decompensation often overlooks the fact that human brain has an inherent capacity to remodel itself in response to insults that affect its function. In the wake of emerging insights into both micro- and macro-scale brain connectivity, a substantial amount of the longitudinal structural changes seen in patients with schizophrenia could result from a distributed, nevertheless inefficient, cortical reorganization response. Quantifying cortical reorganization in the early stages of illness can enable prospective grading of the underlying pathophysiological process in schizophrenia.

Citations

May 2, 2018·JAMA Psychiatry·Tushar DasAndré Schmidt
Jan 18, 2018·Psychological Medicine·Maria Carmela PadulaStephan Eliez
Nov 14, 2018·Brain : a Journal of Neurology·Marc-Antoine d'AlbisJosselin Houenou
May 8, 2018·Psychological Medicine·Lena PalaniyappanPeter Liddle
Aug 7, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ali AmadPierre A Geoffroy
Aug 4, 2020·Schizophrenia Bulletin·Matthias KirschnerBratislav Mišić
Jan 7, 2020·Schizophrenia Bulletin·Yunzhi PanLena Palaniyappan
Nov 25, 2019·Neuroimaging Clinics of North America·André Schmidt, Stefan Borgwardt
Feb 28, 2021·The Australian and New Zealand Journal of Psychiatry·Lena Palaniyappan
Mar 2, 2021·Journal of Psychiatric Research·Francesca SaviolaUNKNOWN GET UP Group
Jan 6, 2021·NeuroImage. Clinical·Samantha V AbramSusanna L Fryer
May 26, 2021·Translational Psychiatry·Daniel J HaukeUNKNOWN PRONIA Group
Sep 12, 2021·Seminars in Cell & Developmental Biology·Lena Palaniyappan

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