Progressive Decline in Estimated GFR in Patients With Sickle Cell Disease: An Observational Cohort Study.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Vimal K DerebailKenneth I Ataga

Abstract

Progression of chronic kidney disease (CKD) in sickle cell disease (SCD) and its risk factors remain poorly defined. We identified characteristics associated with CKD as well as decline in estimated glomerular filtration rate (eGFR) and presence of proteinuria over time in adults with SCD. Retrospective observational study. Patients with SCD 18 years or older in a single center from 2004 to 2013. Baseline clinical and laboratory measures, comorbid conditions, SCD-related complications, relevant treatments, and severity of genotypes defined as severe (homozygous SCD [HbSS]/sickle-β0-thalassemia [HbSβ0]) or mild (hemoglobin SC disease [HbSC]/sickle-β+-thalassemia [HbSβ+]-thalassemia). Presence at baseline of CKD, defined here as eGFR<90mL/min/1.73m2 or proteinuria (≥1+) on urinalysis or current kidney transplant or dialysis therapy; change in eGFR; and presence of proteinuria over time. Logistic regression for baseline CKD. Linear mixed-effects model for eGFR decline and generalized linear mixed-effects model for proteinuria during the study period evaluating for interaction with time. Stratified by genotype severity. Among 427 patients, 331 had 2 or more measurements of creatinine. During a median follow-up of 4.01 (interquartil...Continue Reading

Citations

Dec 8, 2019·Journal of the American Society of Nephrology : JASN·Kabir O OlaniranSahir Kalim
Dec 12, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Maud CazenaveMarie Courbebaisse
Nov 21, 2020·British Journal of Clinical Pharmacology·Claire PressiatPablo Bartolucci
Mar 7, 2021·Journal of Clinical Medicine·Dimitris A TsitsikasRoger J Amos
Jun 17, 2021·British Journal of Haematology·Idris BoudhabhayVincent Audard
May 20, 2021·The Clinical Journal of Pain·Zachary RamsayMonika Asnani
Mar 5, 2021·Journal of Pediatric Hematology/oncology·Amandine RemyNiina Kleiber

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