During the last 30 years, there has been an unexplained trend toward declining values for plethysmographic assessments of lung volume at functional residual capacity (FRC) in infants. The aim of this study was to compare data collected from healthy infants using contemporary equipment with published reference data and to explore reasons for discrepancies. Lung volumes were measured in 32 healthy infants (age, 4-93 weeks; weight, 3.9-12.4 kg) using a new, commercially available infant plethysmograph. Mean (SD) FRC was 19.6 (3.4) ml/kg (within subject coefficient of variation 3.4 [2.3%]), which was on average 7.0 [3.5] ml/kg and 2.3 [1.2] SD (Z) scores lower than the recently collated reference data from an American Thoracic Society task force. A total of 66% of these healthy infants had a FRC that was below the predicted normal range. Comparison of equipment, software, and protocols with those from previous reports revealed the importance of minimization of dead space and of adequate subtraction of all compressible occluded volume when calculating FRC in infants. These findings emphasize the need to establish reference data for lung function tests in infants that are appropriate for the equipment and protocols in current use.
Lung function testing: selection of reference values and interpretative strategies. American Thoracic Society
Should TGV be measured from end-inspiratory occlusions rather than end-expiratory occlusions in wheezy infants?
A method for ventilatory measurements in subjects 1 month--5 years of age: Normal results and observations in disease
Functional residual capacity (FRC) measurements by plethysmography and helium dilution in normal infants
Reference values for residual volume, functional residual capacity and total lung capacity. ATS Workshop on Lung Volume Measurements. Official Statement of The European Respiratory Society
Assessment of functional residual capacity using nitrogen washout and plethysmographic techniques in infants with and without bronchopulmonary dysplasia
Impaired airway function and wheezing in infancy: the influence of maternal smoking and a genetic predisposition to asthma
A simple new technique to measure the effective dead space of the face mask with a water volumeter in infants
Specifications for equipment used for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/ American Thoracic Society
Specification for signal processing and data handling used for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society
Plethysmographic measurements of lung volume and airway resistance. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/ American Thoracic Society
The bias flow nitrogen washout technique for measuring the functional residual capacity in infants. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing
Airway function at one year: association with premorbid airway function, wheezing, and maternal smoking
Decrease of functional residual capacity and ventilation homogeneity after neuromuscular blockade in anesthetized young infants and preschool children
Should inhaled beta-agonists or lung function testing be routine in prematurely born infants with chronic lung disease?
Clinical findings associated with abnormal lung function in children aged 3-26 months with recurrent respiratory symptoms
Updates on Functional Characterization of Bronchopulmonary Dysplasia - The Contribution of Lung Function Testing
Lung Function in Wheezing Infants after Acute Lower Respiratory Tract Infection and Its Association with Respiratory Outcome
Lung function tests in neonates and infants with chronic lung disease of infancy: functional residual capacity
Lung function tests in neonates and infants with chronic lung disease: lung and chest-wall mechanics
A novel physiological investigation of the functional residual capacity by the bias flow nitrogen washout technique in infants
Impact of depth of propofol anaesthesia on functional residual capacity and ventilation distribution in healthy preschool children
American Thoracic Association Journals
Discover the latest respiratory research published by the journals from the American Thoracic Society.