Progressive decline in pulmonary function 5 years post-operatively in patients who underwent anterior instrumentation for surgical correction of adolescent idiopathic scoliosis

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Burt YaszayPeter O Newton

Abstract

To evaluate changes in pulmonary function tests (PFT) at 5 years post-operatively in patients with adolescent idiopathic scoliosis (AIS) and to determine whether these changes are progressive or static after 2 years. AIS surgical patients with pre-operative and 5 year post-operative forced expiratory volume (FEV) and forced vital capacity (FVC) were included. The percentage of patients with pulmonary impairment at 5 years was calculated. Repeated measures ANOVA was used to evaluate changes between pre-operative PFT and 5 years post-operative PFT and to determine whether the changes differed between curve types and approach. A sub-analysis of patients with 2 year data was performed to determine whether PFT changes were static or progressive. Two hundred and sixty-two patients had undergone pre-operative and 5 year post-operative PFTs. At 5 years, 42% were normal, 41% had mild impairment, and 17% had moderate-severe impairment. Overall, there was a decline in % predicted FVC (p < 0.05); FEV remained stable. There was no difference based on major curve type (p > 0.05). Anterior instrumentation cases declined significantly between pre-operative PFT and 5 years post-operative PFT (FEV: - 10% open, - 6% thoracoscopic; FVC: - 13% open...Continue Reading

References

Jun 1, 1992·Spine·W J KinnearI D Johnston
Mar 1, 1984·Spine·S Aaro, C Ohlund
Dec 1, 1993·The American Review of Respiratory Disease·X WangB G Ferris
Aug 1, 1993·The American Review of Respiratory Disease·C KearonK J Killian
Mar 15, 1996·Spine·K B WoodK H Heithoff
May 16, 2002·Clinical Orthopaedics and Related Research·Shih-Hao ChenRobert Wen-Wei Hsu
Sep 6, 2005·The Journal of Bone and Joint Surgery. American Volume·Peter O NewtonThomas G Lowe
Sep 6, 2005·The Journal of Bone and Joint Surgery. American Volume·Shin-Yoon KimKyung-Hoi Koo
Oct 10, 2007·The Spine Journal : Official Journal of the North American Spine Society·Gregory ReddingRobert Campbell
Aug 16, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Burt YaszayPeter O Newton

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Citations

Jan 12, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Robert C Mulholland
Nov 25, 2020·Pediatric Clinics of North America·Diane Dudas Sheehan, John Grayhack

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