Progressive decrease in N-acetylaspartate/Creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury.

AJNR. American Journal of Neuroradiology
Sandra L Wootton-GorgesNicole S Glaser

Abstract

Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.

References

Aug 4, 2004·The Journal of Pediatrics·Nicole S GlaserNathan Kuppermann
Feb 6, 2007·Progress in Neurobiology·John R MoffettAryan M A Namboodiri
Jan 22, 2008·Lancet Neurology·Geert Jan BiesselsChristopher M Ryan
Jul 19, 2008·Journal of Pediatric Psychology·Justine M NaguibM Elena Garralda
Oct 17, 2009·The Journal of Pediatrics·Simona GhettiNicole S Glaser

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Citations

Jul 27, 2015·Pediatric Clinics of North America·Fergus J Cameron
Jan 7, 2017·Journal of Child Neurology·Sherifa HamedTahra Sherief
Mar 10, 2017·Expert Review of Clinical Pharmacology·Sherifa A Hamed
Jun 4, 2018·The Journal of Clinical Endocrinology and Metabolism·Monika Karczewska-KupczewskaEugeniusz Tarasów
Jul 15, 2015·Psychosomatic Medicine·John P RyanCaterina Rosano
Oct 28, 2019·AJNR. American Journal of Neuroradiology·A BerringtonR E Strowd
Dec 5, 2020·JAMA Network Open·Sage R MyersUNKNOWN Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group

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