Progressive dementia after first-ever stroke: a community-based follow-up study

Neurology
V K SrikanthA G Thrift

Abstract

To examine the risk and determinants of a progressive dementia syndrome and cognitive impairment not dementia (CIND) in community-based nonaphasic first-ever stroke cases 1 year after stroke, relative to a matched community-based stroke-free group. Matched cohort design, with cognitive tests given on two occasions 9 months apart to 99 mild-to-moderate first-ever stroke patients and 99 age- and sex-matched people without stroke. At follow-up, progressive dementia or CIND were diagnosed, with judges blinded to stroke/nonstroke status. Progressive dementia was diagnosed in 12.5% of stroke patients and 15.4% of those without strokes (RR 1.1, 95% CI 0.5 to 2.2, p = 0.85). CIND was diagnosed in 37.5% of stroke patients and 17.6% of participants without strokes (RR 2.1, 95% CI 1.2 to 3.4, p = 0.003). In multivariable regression, age (p = 0.04) and baseline cognition (p < 0.001) were independently associated with dementia whereas stroke (p = 0.002), age (p = 0.05), baseline cognition (p = 0.001), and baseline mood (p = 0.03) were independently associated with CIND at follow-up. In this community-based nonaphasic sample, mild-to moderate first-ever stroke was not associated with the presence of progressive dementia 1 year later, but was...Continue Reading

Citations

Aug 9, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Hyun Ah KimChristopher G Sobey
Feb 8, 2007·Acta Neuropathologica·Kurt A Jellinger
Dec 16, 2006·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Marina CaoMaurizia Rasura
Jul 3, 2010·Journal of the International Neuropsychological Society : JINS·Nikki H StrickerKathleen Y Haaland
Jul 9, 2008·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Laura MansuetiRoger A Dixon
May 21, 2013·The Clinical Neuropsychologist·Dalin T PulsipherKathleen Y Haaland
Aug 19, 2008·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Kerstin WendelSusanne Iwarsson
Aug 19, 2007·Dementia and Geriatric Cognitive Disorders·Diana De RonchiLaura Fratiglioni
Feb 24, 2007·Vascular Health and Risk Management·Marcus B Nicol, Amanda G Thrift
Jun 23, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sujata DasShyamal Kumar Das
Jul 9, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·James F MeschiaRobert D Brown
May 15, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Claudia JacovaOscar R Benavente
Oct 30, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Galit WeinsteinSudha Seshadri
Oct 22, 2005·Lancet Neurology·Didier LeysFlorence Pasquier
Jul 19, 2005·Neurobiology of Aging·Francesco PanzaVincenzo Solfrizzi
Mar 25, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Perminder S SachdevHenry Brodaty
May 5, 2016·Acta Neurologica Scandinavica·J GuoX Guo
Feb 18, 2017·Nature Reviews. Neurology·Vincent C T MokLawrence K S Wong
May 13, 2006·Journal of Geriatric Psychiatry and Neurology·Wai Kwong TangAnil T Ahuja
May 21, 2013·Stroke; a Journal of Cerebral Circulation·Pamela M RistChristophe Tzourio
Jul 10, 2014·Stroke; a Journal of Cerebral Circulation·Alexander ThielShawn N Whitehead
Jan 15, 2011·Stroke; a Journal of Cerebral Circulation·Yannick BéjotMaurice Giroud
Nov 17, 2009·Stroke; a Journal of Cerebral Circulation·George M SavvaUNKNOWN Alzheimer's Society Vascular Dementia Systematic Review Group
Apr 29, 2006·Cerebrovascular Diseases·H HénonD Leys
Sep 5, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Elżbieta KuźmaDavid J Llewellyn
Dec 29, 2020·Brain Research Bulletin·Ankan SarkarPallab Bhattacharya
Apr 29, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M A Grigolashvili, R M Mustafina

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