Progressive detachment of cells from surfaces: a consequence of heterogeneous ligand populations or a multi-site binding equilibrium?

Journal of Theoretical Biology
J HubbleW Whish

Abstract

A multi-site binding equilibrium model is proposed to describe the effect of applied shear on the detachment of affinity adsorbed particles or cells from surfaces. Unlike earlier models used to describe this phenomenon the current approach considers the extent to which multiple interactions show surface cooperativity such that the attached fraction can be described in terms of a number of subpopulations linked via differing numbers of ligand/receptor interactions.

Citations

May 23, 2020·Acta Biomaterialia·Kaitlyn BaconStefano Menegatti
Jun 11, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Sanya SiddiquiChristopher Moraes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.