Progressive development of cardiomyopathy following altered autonomic activity in status epilepticus

American Journal of Physiology. Heart and Circulatory Physiology
M I ReadIvan A Sammut

Abstract

Seizures are associated with altered autonomic activity, which has been implicated in the development of cardiac dysfunction and structural damage. This study aimed to investigate the involvement of the autonomic nervous system in seizure-induced cardiomyopathy. Male Sprague-Dawley rats (320-350 g) were implanted with EEG/ECG electrodes to allow simultaneous telemetric recordings during seizures induced by intrahippocampal (2 nmol, 1 μl/min) kainic acid and monitored for 7 days. Seizure activity occurred in conjunction with increased heart rate (20%), blood pressure (25%), and QTc prolongation (15%). This increased sympathetic activity was confirmed by the presence of raised plasma noradrenaline levels at 3 h post-seizure induction. By 48 h post-seizure induction, sympathovagal balance was shifted in favor of sympathetic dominance, as indicated by both heart rate variability (LF/HF ratio of 3.5 ± 1.0) and pharmacological autonomic blockade. Functional cardiac deficits were evident at 7 and 28 days, as demonstrated by echocardiography showing a decreased ejection fraction (14% compared with control, P < 0.05) and dilated cardiomyopathy present at 28 days following seizure induction. Histological changes, including cardiomyocyte ...Continue Reading

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Citations

Jan 16, 2016·Autonomic Neuroscience : Basic & Clinical·Halil SayinClaude Julien
Sep 23, 2020·Annals of the New York Academy of Sciences·Laxmikant S DeshpandeRobert J DeLorenzo
Nov 20, 2021·Clinical and Experimental Pharmacology & Physiology·Inas A HarbEman Hassan Nadwa

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