Progressive dysexecutive syndrome due to Alzheimer's disease: a description of 55 cases and comparison to other phenotypes

Brain Communications
Ryan A TownleyDavid T Jones

Abstract

We report a group of patients presenting with a progressive dementia syndrome characterized by predominant dysfunction in core executive functions, relatively young age of onset and positive biomarkers for Alzheimer's pathophysiology. Atypical frontal, dysexecutive/behavioural variants and early-onset variants of Alzheimer's disease have been previously reported, but no diagnostic criteria exist for a progressive dysexecutive syndrome. In this retrospective review, we report on 55 participants diagnosed with a clinically defined progressive dysexecutive syndrome with 18F-fluorodeoxyglucose-positron emission tomography and Alzheimer's disease biomarkers available. Sixty-two per cent of participants were female with a mean of 15.2 years of education. The mean age of reported symptom onset was 53.8 years while the mean age at diagnosis was 57.2 years. Participants and informants commonly referred to initial cognitive symptoms as 'memory problems' but upon further inquiry described problems with core executive functions of working memory, cognitive flexibility and cognitive inhibitory control. Multi-domain cognitive impairment was evident in neuropsychological testing with executive dysfunction most consistently affected. The front...Continue Reading

References

Feb 1, 1992·Neurology·R C PetersenE G Tangalos
Jan 31, 1992·Science·A Baddeley
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Dec 1, 1991·Brain : a Journal of Neurology·A D BaddeleyH Spinnler
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·A Baddeley
Dec 31, 1997·Journal of Clinical and Experimental Neuropsychology·R J IvnikR C Petersen
Oct 20, 1998·Journal of Clinical and Experimental Neuropsychology·J A LucasR C Petersen
Dec 22, 1998·American Journal of Ophthalmology·P W BrazisA G Lee
Oct 16, 1999·Archives of Neurology·J K JohnsonC W Cotman
Apr 19, 2000·Journal of Cognitive Neuroscience·R Cabeza, L Nyberg
Oct 3, 2003·Nature Reviews. Neuroscience·Alan Baddeley
Oct 31, 2003·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Henrik WalterManfred Spitzer
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
May 15, 2007·Journal of Clinical and Experimental Neuropsychology·M M MachuldaE G Tangalos
Feb 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Clifford R JackMichael W Weiner
Oct 30, 2008·Current Neurology and Neuroscience Reports·Rachel Goldmann Gross, Murray Grossman
Apr 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yong-Jie ZhangLeonard Petrucelli
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·J Matias PalvaSatu Palva
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·David A WolkUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 22, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Bradford C DickersonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 7, 2010·The Clinical Neuropsychologist·Julie A FieldsGlenn E Smith
Oct 26, 2010·Trends in Biotechnology·Christian Humpel
Jan 18, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Cheryl L StopfordJulie S Snowden
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
Mar 19, 2011·Nature Reviews. Neuroscience·Dwight J KravitzMortimer Mishkin
Oct 4, 2011·Annual Review of Psychology·Alan Baddeley
Jan 24, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bradley T HymanThomas J Montine
Mar 16, 2012·Brain : a Journal of Neurology·Cibu ThomasMoshe Bar
Jul 5, 2012·PloS One·David T JonesClifford R Jack
Jul 18, 2012·Nature Reviews. Neurology·Jason D WarrenHannah L Golden
Aug 9, 2012·American Journal of Alzheimer's Disease and Other Dementias·Mario F MendezJill S Shapira
Sep 20, 2012·American Journal of Alzheimer's Disease and Other Dementias·Natalie C KaiserMario F Mendez

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Citations

Oct 24, 2020·Brain : a Journal of Neurology·Clifford R JackRonald C Petersen
Feb 5, 2021·Nature Reviews. Neuroscience·Lucina Q Uddin
Nov 16, 2020·Alzheimer's Research & Therapy·Ellen H SingletonRik Ossenkoppele
Feb 18, 2021·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Yat-Fung SheaHon-Wai Felix Chan
Feb 21, 2021·Lancet Neurology·Jonathan Graff-RadfordMelissa E Murray
Apr 15, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Ellen SingletonRik Ossenkoppele
May 15, 2021·Nature Reviews. Disease Primers·David S KnopmanDavid T Jones
Jul 6, 2021·Brain Communications·Flavia LoretoParesh A Malhotra
Jun 22, 2021·NeuroImage. Clinical·Colin GrootUNKNOWN Alzheimer's disease neuroimaging initiative (ADNI)

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
dissection

Software Mentioned

MOANS
SPM12
FreeSurfer
CortexID
R
MATLAB
ggplot2

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