Progressive Gait Deficits in Parkinson's Disease: A Wearable-Based Biannual 5-Year Prospective Study

Frontiers in Aging Neuroscience
Markus A HobertSebastian Heinzel

Abstract

Background: Gait changes occur during all Parkinson's disease (PD) stages and wearable sensor-derived gait parameters may quantify PD progression. However, key aspects that may qualify quantitative gait parameters as progression markers in PD remain elusive. Objectives: Longitudinal changes in gait parameters from a lower-back sensor under convenient and challenging walking conditions in early- and mid-stage PD patients (E-PD, M-PD) compared to controls were investigated. Methods: Normal- and fast-pace parameters (step: number, time, velocity, variability) were assessed every 6 months for up to 5 years in 22 E-PD (<4 years baseline disease duration), 18 M-PD (>5 years) and 24 controls. Parameter trajectories and associations with MDS-UPDRS-III were tested using generalized estimating equations. Results: Normal-pace step number (annual change in E-PD: 2.1%, Time∗Group: p = 0.001) and step time variability (8.5%, p < 0.05) longitudinally increased in E-PD compared to controls (0.7%, -12%). For fast pace, no significant progression differences between groups were observed. Longitudinal changes in M-PD did not differ significantly from controls. MDS-UPDRS-III was largely associated with normal-pace parameters in M-PD. Conclusion: W...Continue Reading

References

Feb 1, 1993·Archives of Neurology·A J HughesA J Lees
Mar 19, 2003·Journal of Geriatric Psychiatry and Neurology·Jeffrey M HausdorffNir Giladi
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Aug 24, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Bart PostJohannes D Speelman
Jan 24, 2006·Gait & Posture·Mirko BrandesDieter Rosenbaum
Nov 23, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzNancy LaPelle
Mar 27, 2007·Gait & Posture·U LindemannK Aminian
Jan 8, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Nir GiladiEduardo Tolosa
Feb 21, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·M PlotnikJ M Hausdorff
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Charlotte A HaaxmaMartin W I M Horstink
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Jul 26, 2013·Brain : a Journal of Neurology·Jeffrey H KordowerRaymond T Bartus
Dec 30, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Brook GalnaLynn Rochester
Mar 22, 2016·Parkinsonism & Related Disorders·Sebastian HeinzelWalter Maetzler
May 31, 2016·Parkinsonism & Related Disorders·Chae Won ShinBeomseok Jeon
Jun 10, 2017·Frontiers in Aging Neuroscience·Markus A HobertWalter Maetzler
Jul 7, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Sebastian HeinzelDaniela Berg
Jul 22, 2017·International Journal of Geriatric Psychiatry·Nicole CarsonKelly J Murphy
Oct 12, 2017·PloS One·Johannes C M SchlachetzkiJochen Klucken
Jan 31, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Caroline MoreauUNKNOWN FAIRPARK-II study group
Nov 8, 2018·Journal of Parkinson's Disease·Kalpana M MerchantUNKNOWN and The Michael J. Fox Foundation Alpha Synuclein Clinical Path Working Group

❮ Previous
Next ❯

Citations

Jul 12, 2019·Annals of Neurology·Silvia Del DinWalter Maetzler
Aug 15, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Sebastian HeinzelUNKNOWN MDS Task Force on the Definition of Parkinson's Disease
Dec 15, 2019·Sensors·Niveditha MuthukrishnanNarayanan Krishnamurthi
Oct 10, 2020·Journal of Medical Internet Research·Luc Jw EversBastiaan R Bloem
Nov 17, 2020·Frontiers in Aging Neuroscience·Joanna WilsonBrook Galna
Jan 1, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Joanna WilsonLynn Rochester
Mar 5, 2021·Current Neurology and Neuroscience Reports·Jamie L AdamsRuth B Schneider
Apr 4, 2021·Sensors·Julius WelzelWalter Maetzler
Apr 22, 2021·Nature Reviews. Neurology·Daniela BergRonald B Postuma
Sep 24, 2021·Neurorehabilitation and Neural Repair·Deepak K RaviNavrag B Singh

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.