Progressive gender differences of structural brain networks in healthy adults: a longitudinal, diffusion tensor imaging study

PloS One
Yu SunKang Sim

Abstract

Sexual dimorphism in the brain maturation during childhood and adolescence has been repeatedly documented, which may underlie the differences in behaviors and cognitive performance. However, our understanding of how gender modulates the development of structural connectome in healthy adults is still not entirely clear. Here we utilized graph theoretical analysis of longitudinal diffusion tensor imaging data over a five-year period to investigate the progressive gender differences of brain network topology. The brain networks of both genders showed prominent economical "small-world" architecture (high local clustering and short paths between nodes). Additional analysis revealed a more economical "small-world" architecture in females as well as a greater global efficiency in males regardless of scan time point. At the regional level, both increased and decreased efficiency were found across the cerebral cortex for both males and females, indicating a compensation mechanism of cortical network reorganization over time. Furthermore, we found that weighted clustering coefficient exhibited significant gender-time interactions, implying different development trends between males and females. Moreover, several specific brain regions (e...Continue Reading

References

Jun 12, 1998·Nature·D J Watts, S H Strogatz
Jul 2, 1998·Brain : a Journal of Neurology·M M Mesulam
Jul 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·J N GieddF X Castellanos
Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
Nov 3, 2001·Physical Review Letters·V Latora, M Marchiori
Jan 16, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ruben C GurRaquel E Gur
May 4, 2002·Science·Sergei Maslov, Kim Sneppen
Aug 17, 2002·Cerebral Cortex·Ruben C GurRaquel E Gur
Dec 19, 2002·NMR in Biomedicine·Susumu Mori, Peter C M van Zijl
Aug 5, 2004·Brain : a Journal of Neurology·Amanda EllisonA David Milner
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sophie AchardEd Bullmore
Apr 18, 2006·Proceedings. Biological Sciences·M D HumphriesT J Prescott
Feb 6, 2007·PLoS Computational Biology·Sophie Achard, Ed Bullmore
Jun 5, 2007·Biological Psychiatry·Kelly P CosgroveJulie K Staley
Dec 7, 2007·Neuron·Jessica R Andrews-HannaRandy L Buckner
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Nov 28, 2008·Annual Review of Psychology·Denise C Park, Patricia Reuter-Lorenz
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Nov 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eileen LudersArthur W Toga
Dec 29, 2009·NeuroImage·Andrew ZaleskyEdward T Bullmore
Jul 2, 2010·Frontiers in Systems Neuroscience·Alex FornitoEdward T Bullmore
Sep 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Armin RaznahanJay N Giedd
Oct 5, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ai-Min Bao, Dick F Swaab
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chun-Yi LoChing-Po Lin
Jan 22, 2011·Annals of the New York Academy of Sciences·Olaf Sporns
Apr 6, 2011·Psychological Bulletin·Timothy A Salthouse
Apr 30, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Gaolang GongAlan C Evans
May 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Armin RaznahanJay N Giedd

❮ Previous
Next ❯

Citations

Sep 25, 2015·Brain Imaging and Behavior·Anna AltbäckerJózsef Janszky
Aug 21, 2019·Scientific Reports·Bosiljka TadićRoderick Melnik
Oct 27, 2018·European Archives of Psychiatry and Clinical Neuroscience·Frauke Schultze-LutterStefanie J Schmidt
Jul 19, 2018·Frontiers in Physiology·Cristina Carvalho, Paula I Moreira
Oct 24, 2019·Journal of Attention Disorders·Bing WangShuo Zhao
May 28, 2017·Scientific Reports·Hunki KwonJong-Min Lee
Jul 18, 2018·Neuroinformatics·Sebastian SchwankeOliver Schmitt
Jan 8, 2019·Aphasiology·Rajani SebastianDonna C Tippett
Jun 2, 2020·World Journal of Psychiatry·Frauke Schultze-LutterChantal Michel
May 14, 2017·Experimental Brain Research·Agostina Casamento-MoranEvangelos A Christou
Jan 26, 2021·Frontiers in Neuroscience·Mariachiara LongarzoCarlo Cavaliere
Oct 16, 2020·Scientific Reports·Miroslav AndjelkovićRoderick Melnik

❮ Previous
Next ❯

Methods Mentioned

BETA
SMA

Software Mentioned

PANDA
BrainNet Viewer
SPSS
diffusion toolkit
FSL
Brain Connectivity Toolbox

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.