Progressive increase of T1 signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images in the pediatric brain exposed to multiple doses of gadolinium contrast

Brain & Development
Donna R Roberts, Kenton R Holden

Abstract

Recently, there have been reports of gadolinium accumulation in the brain and bone of adult patients with normal renal function who have undergone multiple gadolinium contrast administrations. This case report gives the first description of a pediatric patient who, following multiple contrasted MRI exams, demonstrated abnormal signal on unenhanced T1-weighted imaging involving the dentate nucleus and globus pallidus, a finding which has previously been shown to represent gadolinium deposition in adults. The patient presented here had no history of intracranial pathology which would alter the blood brain barrier or abnormal renal function. The clinical significance of gadolinium accumulation in the human body is currently unknown but is of concern, particularly in pediatric patients who have a lifetime to manifest any potential adverse consequences. Therefore, research is needed to address the clinical significance, if any, of gadolinium deposition in the developing pediatric brain. Given these current uncertainties, clinicians should continue to use prudence in selecting pediatric patients to undergo contrasted MRI and in selecting the appropriate contrast agents to use.

References

Mar 18, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Marc PortClaire Corot
Dec 20, 2011·NeuroImage·Sarah-Jayne Blakemore
Mar 6, 2015·Radiology·Robert J McDonaldLaurence J Eckel

❮ Previous
Next ❯

Citations

Nov 27, 2015·Japanese Journal of Radiology·Tomonori KandaShigeru Furui
Dec 27, 2015·La Radiologia medica·Bruno Beomonte ZobelRosario Francesco Grasso
May 28, 2016·Pediatric Radiology·Anuradha Shenoy-Bhangle, Michael S Gee
Sep 11, 2016·Magnetic Resonance Imaging·Tomonori KandaShigeru Furui
Sep 13, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Maryam Ghadimi MahaniRajesh Krishnamurthy
Oct 4, 2016·Magnetic Resonance Imaging·Joana RamalhoRichard C Semelka
Dec 23, 2016·Radiology·Carlo Cosimo Quattrocchi, Aart J van der Molen
Sep 30, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Ludwig SchlemmMichael Scheel
Apr 1, 2017·La Radiologia medica·Enrico TedeschiArturo Brunetti
Mar 10, 2017·Topics in Magnetic Resonance Imaging : TMRI·Hannes KrollMichael Iv
Jun 28, 2017·Lancet Neurology·Vikas GulaniUNKNOWN International Society for Magnetic Resonance in Medicine
Mar 7, 2018·CNS Drugs·Luca PasquiniMaria Camilla Rossi Espagnet
Mar 11, 2018·Clinical Neuroradiology·Richard PullicinoKumar Das
Aug 29, 2018·American Journal of Veterinary Research·Jennifer M GambinoAlison M Lee
Nov 16, 2018·Journal of Clinical Neuromuscular Disease·Sabrina PoonjaSteven C Greenway
Sep 1, 2018·Anesthesia and Analgesia·Honorio T BenzonHubert A Benzon
Sep 27, 2018·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Andreu F CostaNicola Schieda
Oct 31, 2019·Journal of Magnetic Resonance Imaging : JMRI·Elif Dilara TopcuogluYasar Bukte
Apr 5, 2020·Journal of Magnetic Resonance Imaging : JMRI·Marlène RasschaertJean-Marc Idée
May 7, 2020·AJR. American Journal of Roentgenology·Emily A EdwardsJesse Courtier
Jul 19, 2016·Current Opinion in Pediatrics·Puja Banka, Tal Geva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.