Progressive Induction of Type 2 Diabetes: Effects of a Reality-Like Fructose Enriched Diet in Young Wistar Rats

PloS One
Julie DupasJacques Mansourati

Abstract

The aim of this study was to characterize short and medium-lasting effects of fructose supplementation on young Wistar rats. The diet was similar to actual human consumption. Three week old male rats were randomly divided into 2 groups: control (C; n = 16), fructose fed (FF; n = 16) with a fructose enriched drink for 6 or 12 weeks. Bodyweight, fasting glycemia and systolic blood pressure were monitored. Glucose tolerance was evaluated using an oral glucose tolerance test. Insulinemia was measured concomitantly and enable us to calculate insulin resistance markers (HOMA-IR, Insulin Sensitivity Index for glycemia: ISI-gly). Blood chemistry analyses were performed. After six weeks of fructose supplementation, rats were not overweight but presented increased fasting glycemia, reduced glucose tolerance, and lower insulin sensitivity compared to control group. Systolic blood pressure and heart weight were also increased without any change in renal function (theoretical creatinine clearance). After twelve weeks of fructose supplementation, FF rats had increased bodyweight and presented insulin resistance (higher HOMA-IR, lower ISI-gly). Rats also presented higher heart volume and lower ASAT/ALAT ratio (presumed liver lesion). Surprisi...Continue Reading

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Citations

May 10, 2018·Nature Reviews. Gastroenterology & Hepatology·Susanne SchusterAriel E Feldstein
May 13, 2017·BioMed Research International·Julie DupasJacques Mansourati
Dec 21, 2016·Archives of Toxicology·Salamah Mohammad Alwahsh, Rolf Gebhardt
Oct 12, 2018·Nutrition & Metabolism·Julie DupasChristelle Goanvec
Dec 30, 2020·Biomolecules·Clémence RivesWalter Wahli
Jul 25, 2018·Journal of Agricultural and Food Chemistry·Yu-Sheng ShiWen-Zhong Hu

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Methods Mentioned

BETA
ELISA

Software Mentioned

ISI
HOMA
gly
IR calculator

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