Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline-treated rats

Microvascular Research
D W WilsonS D Dunston

Abstract

The progression of changes in the bronchus-associated and intraacinar pulmonary arteries of rats treated with a single dose of monocrotaline (60 mg/kg) was evaluated by quantitative light and electron microscopy. The relative volume of vessel wall components was normalized to the surface area of the adventitial sheath. An increased relative volume of media was evident in intraacinar pulmonary arteries by 4 hr post-treatment. This increase may represent vascular smooth muscle contraction. Significant increases in adventitial mononuclear inflammatory cells were evident by 8-16 hr post-treatment in intraacinar pulmonary arteries and veins but not until 14 days post-treatment in major, bronchus-associated pulmonary arteries. Inflammatory cell influxes were associated with increased relative volume of adventitia, largely due to increased extracellular space. By 22 days posttreatment, there was right ventricular hypertrophy and a marked mononuclear vasculitis in major and intraacinar pulmonary arteries as well as intraacinar veins (confirmed as such by vascular perfusion of carbon/gelatin). There was increased relative medial volume in both major and intraacinar pulmonary arteries associated with increased extracellular matrix compos...Continue Reading

References

Jun 1, 1967·Angiology·E ValdiviaJ J Lalich
Nov 1, 1983·Circulation Research·R F Furchgott

❮ Previous
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Citations

Aug 3, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gopinath SutendraEvangelos D Michelakis
Feb 6, 1990·European Journal of Pharmacology·J C Wanstall, S R O'Donnell
May 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M J ReidH J Segall
May 4, 2011·La Presse médicale·Frédéric PerrosMarc Humbert
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·L WrightN F Voelkel
Jul 3, 1998·American Journal of Respiratory Cell and Molecular Biology·H C ThomasH J Segall
Sep 4, 2010·American Journal of Respiratory Cell and Molecular Biology·Michael J CutticaManfred Boehm
Jul 15, 1996·The Journal of Clinical Investigation·Y TanakaM D Botney
Mar 5, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ioana R PrestonIris Z Jaffe
Dec 25, 2012·Pharmacology & Therapeutics·Sy Duong-QuyAnh Tuan Dinh-Xuan
Jul 21, 2007·The American Journal of Pathology·Steve D SwainAllen G Harmsen
Mar 13, 2014·International Journal of Rheumatic Diseases·Ling-Ling ZhangXiao-Feng Zeng
May 10, 2006·Journal of Biomechanics·E S DrexlerR Shandas
Aug 26, 1998·Toxicology and Applied Pharmacology·H C ThomasD W Wilson
Aug 17, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yi-Cheng YangS W Annie Bligh
Nov 16, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Hsao-Hsun HsuChau-Fong Chen
Jan 1, 1992·Critical Reviews in Toxicology·D W WilsonD Morin
Jul 17, 1998·The Journal of Laboratory and Clinical Medicine·R M Tuder, N F Voelkel
Jan 1, 1996·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·B L StegelmeierR J Molyneux
Aug 18, 2017·Physiology·Diana M TabimaNaomi C Chesler
Dec 17, 2010·World Journal of Cardiology·Vincent G DemarcoKevin C Dellsperger
Oct 8, 2014·Circulation Research·Roxane PaulinEvangelos D Michelakis
Feb 21, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rui XiaoQinghua Hu
Mar 17, 2007·American Journal of Respiratory Cell and Molecular Biology·Pravin B Sehgal, Somshuvra Mukhopadhyay
Jul 31, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Magdalena StroblDiana Bonderman
Apr 19, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karl-Otto LarsenOle Henning Skjønsberg
Jan 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·John E JonesYing-Yi Zhang
Nov 17, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mark L OrmistonDavid W Courtman
Jul 6, 2000·The Journal of Biological Chemistry·M W LaméH J Segall

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