PMID: 6971794Mar 1, 1981Paper

Progressive inhibition of human glandular (urinary) kallikrein by human serum and identification of the progressive antikallikrein as alpha 1-antitrypsin (alpha 1-protease inhibitor)

Hoppe-Seyler's Zeitschrift für physiologische Chemie
R GeigerH Fritz

Abstract

Human urinary kallikrein was inhibited by human alpha 1-antitrypsin (alpha 1-protease inhibitor) in a similar way as by equivalent amounts of human serum. The inhibitor present in the kallikrein-inhibitor complex formed was identified as alpha 1-antitrypsin by two-dimensional immunoelectrophoresis. Under the experimental conditions applied, 90 mIU (= 185 microgram) alpha 1-antitrypsin inhibits about 9 microgram of human urinary kallikrein in 24 h at 37 degrees C, 1 ml of human serum, containing 2-4 mg alpha 1-antitrypsin, inhibits about 70 microgram kallikrein. At an incubation temperature of 25 degrees C, the rate of inactivation is significantly lower than at 37 degrees C. No inhibition was observed at 0 degrees C or when alpha 1-antitrypsin was presaturated with trypsin.

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Citations

Jan 1, 1984·Hoppe-Seyler's Zeitschrift für physiologische Chemie·K HiranoM Sugiura
Dec 1, 1995·European Journal of Biochemistry·F EspañaK Witzgall
Nov 1, 1996·The Journal of Biological Chemistry·L M ChenJ Chao
Apr 13, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·M Bläckberg, K Ohlsson
Sep 1, 1985·Biological Chemistry Hoppe-Seyler·E FinkK Shimamoto
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·N UraO Iimura
Sep 14, 2012·Expert Opinion on Pharmacotherapy·Delphine CharignonChristian Drouet
Jan 1, 1991·Acta Oto-laryngologica·S Lindberg, H Olsson
Nov 1, 1982·Hoppe-Seyler's Zeitschrift für physiologische Chemie·E Fink, M Schleuning
Jan 1, 1982·European Journal of Clinical Pharmacology·W H HörlA Heidland
May 6, 1998·Protein Science : a Publication of the Protein Society·B A KatzE B Springman
Dec 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation·M Bläckberg, K Ohlsson
Dec 1, 1995·Biological Chemistry Hoppe-Seyler·L PeltonenJ Aaltonen
Feb 12, 1998·Biochimica Et Biophysica Acta·K X ChaiJ Chao
May 1, 1996·Immunopharmacology·J ChaoL Chao
Nov 1, 1997·Trends in Cardiovascular Medicine·J Chao, L Chao
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Jan 1, 1986·Kidney International·A G Scicli, O A Carretero
Jul 10, 2010·Biochimie·Peter GoettigHans Brandstetter

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