PMID: 6445042Apr 10, 1980

Progressive inhibition of the Ca pump and Ca:Ca exchange in sickle red cells

Nature
Robert M Bookchin, Virgilio L Lew

Abstract

Sickle cell anaemia red cells (SS) were reported to have a high Ca content and an increased Ca uptake on deoxygenation, but their Ca-pump activity was described as normal. This seemed puzzling because the saturated Ca-extrusion rate of the normal, high Ca-affinity Ca pump is about 10 mmol per 1 cells per h (refs 3, 4) and the highest sickling-induced Ca influx reported in SS cells and observed in ATP-depleted sickle-trait (SA) red cells never exceeded 0.2 mmol per 1 cells per h. Normal pump performance is, therefore, incompatible with Ca accumulation unless SS cells have abnormally high Ca-binding capacity. We provide here evidence which suggests that SS cells have normal Ca-buffering capacity and probably genetically normal Ca pumps, but that the sickling process causes progressive Ca-pump failure and a marked reduction in Ca:Ca exchange.

References

Feb 14, 1975·Biochimica Et Biophysica Acta·S FischerI Tellez-Nagel
Nov 9, 1973·Nature·J W EatonH S Jacob
Dec 1, 1968·The Journal of Physiology·D G Harrison, C Long

Citations

Dec 1, 1993·Community Mental Health Journal·C I Cohen
Jan 1, 1987·The Journal of Membrane Biology·B Engelmann, J Duhm
Sep 22, 2010·Pflügers Archiv : European journal of physiology·Michael FöllerStephan M Huber
Jan 1, 1982·Pharmacology & Therapeutics·J S Wiley, K E McCulloch
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·P W Flatman, P L Andrews
Nov 13, 1991·Biochimica Et Biophysica Acta·A J Schroit, R F Zwaal
Nov 1, 1981·The Journal of Clinical Investigation·L R Berkowitz, E P Orringer
Feb 4, 1982·Biochimica Et Biophysica Acta·V W MacDonald, S Charache
Jun 13, 1985·Nature·Virgilio L LewRobert M Bookchin
Jun 10, 2009·Biotechnology Journal·Petra Rohrbach
Oct 16, 1980·Biochimica Et Biophysica Acta·Virgilio L Lew, Robert M Bookchin
Oct 1, 1985·Cell Calcium·M D RhodaY Beuzard
Jan 1, 1986·Annals of the New York Academy of Sciences·A V SomlyoA P Somlyo
Jan 1, 1981·American Journal of Hematology·E F RothRobert M Bookchin
Dec 1, 1996·Hematology/oncology Clinics of North America·Robert M Bookchin, Virgilio L Lew
Nov 20, 1981·Biochimica Et Biophysica Acta·S Thompson, A H Maddy
May 24, 2013·International Journal of Molecular Sciences·Anna BogdanovaLars Kaestner
Dec 25, 2004·Physiological Reviews·Virgilio L Lew, Robert M Bookchin
Jun 19, 2018·Frontiers in Physiology·Rick HuisjesRichard van Wijk
Aug 1, 2020·Frontiers in Cell and Developmental Biology·Michael Föller, Florian Lang
Feb 1, 1993·The American Journal of Physiology·C H Joiner

Related Concepts

Calcimycin
Ca(2+)-Transporting ATPase
Anemia, Sickle Cell
Calcium
Abnormal Red Blood Cell

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