Progressive juvenile glomerulonephropathy in 16 related French Mastiff (Bordeaux) dogs

Journal of Veterinary Internal Medicine
R LavouéD Peeters

Abstract

Familial juvenile glomerulonephropathy (JGN) is reported in several breeds of dogs. The mode of inheritance and spectrum of pathological lesions vary among breeds. A progressive JGN was detected in a pedigree of French Mastiff (FM) dogs. To describe clinical, laboratory, and histopathologic findings in related FM dogs suffering from progressive JGN and to determine the mode of inheritance of this condition. Sixteen affected and 35 healthy related FM dogs FM dogs < 24 months of age and diagnosed with chronic kidney disease with evidence of proteinuria entered the study. Clinical, laboratory, histopathologic findings, and pedigree data were recorded. Clinical signs were typical of progressive glomerulopathy with resultant renal failure. Increased blood urea nitrogen, creatinine and total cholesterol concentrations, and proteinuria were found in all patients. Affected dogs had abnormal kidney structure on abdominal ultrasound examination. Histopathologic examination revealed extensive cystic glomerular atrophy, glomerular hypercellularity, and capillary wall thickening without immune complex deposition when tested with immunohistochemistry or immunofluorescence. Electron microscopy did not disclose specific primary glomerular lesi...Continue Reading

References

Jul 1, 1989·Australian Veterinary Journal·W F RobinsonR Mitten
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·P S ThornerP M Marrano
Jan 1, 1988·Journal of Clinical Epidemiology·H PaltiE Belmaker
Mar 1, 1995·Kidney International·J C HoodW F Robinson
Jul 1, 1994·Veterinary Pathology·G MinkusW Hermanns
May 1, 1994·Veterinary Pathology·M Vilafranca, L Ferrer
Jul 1, 1996·Journal of the American Animal Hospital Association·A K Cook, L D Cowgill
Nov 1, 1996·Kidney International·C E Kashtan, A F Michael
Mar 1, 1997·Journal of Veterinary Internal Medicine·G E LeesM S Frey
May 20, 1998·Journal of the American Animal Hospital Association·G E LeesM S Frey
Mar 24, 1999·Journal of Comparative Pathology·A J GermanM J Day
Jan 19, 2000·Journal of the American Veterinary Medical Association·J Y RhaJ Alroy
Jun 21, 2001·Molecular and Cellular Biology·D B DonovielD R Powell
Feb 13, 2002·The American Journal of Pathology·Kaya L AndrewsJeffrey H Miner
Nov 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jennifer C HoodJudy Savige
Feb 5, 2003·Journal of the American Veterinary Medical Association·Frédéric JacobLaurie L Swanson
May 23, 2003·Journal of the American Society of Nephrology : JASN·Marie-Claire Gubler
Jun 5, 2003·The Journal of Clinical Investigation·Claudine H KosMartin R Pollak
Jul 25, 2003·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Melissa L CoxKeith E Murphy
Jan 1, 2004·Molecular and Cellular Biology·Séverine RoselliCorinne Antignac
Jul 3, 2004·Veterinary Pathology·M L CasalP S Henthorn
Jun 1, 1989·New Zealand Veterinary Journal·B R JonesE Davies
Sep 8, 2005·Veterinary Pathology·C A BrownS A Brown
Nov 18, 2005·Trends in Molecular Medicine·Wilhelm Kriz
Sep 8, 2006·Kidney International·S V Dandapani, M R Pollak
Nov 23, 2006·Intensive Care Medicine·Giuseppe ServilloRosalba Tufano
Aug 19, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ali Mirza OnderGaston Zilleruelo
Dec 21, 2007·Nature Clinical Practice. Nephrology·Marie Claire Gubler

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Citations

Aug 13, 2011·The Journal of Veterinary Medical Science·Angelo BasileLuca Aresu
Jan 22, 2011·The Veterinary Clinics of North America. Small Animal Practice·Meryl P Littman
Jan 22, 2011·The Veterinary Clinics of North America. Small Animal Practice·Harriet Syme
Aug 3, 2013·Veterinary Clinical Pathology·R LavouéC Trumel
May 7, 2014·Veterinary Clinical Pathology·R LavouéC Trumel
Oct 29, 2015·Veterinary Pathology·R E CiancioloL Aresu

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