PMID: 2462516Jan 1, 1988

Progressive loss of neuronal src protein in postnatal weaver and staggerer cerebellum

Experimental Cell Biology
O D WiestlerG Walter

Abstract

Two forms of the c-src protein-tyrosine kinase, pp60c-src, are detectable in the central nervous system. One form pp60+, appears to be exclusively expressed in neurons and is characterized by insertion of 6 amino acids compared to its non-neuronal counterpart, pp60. These 2 proteins were studied in the mutant mouse strains weaver and staggerer with postnatal loss of cerebellar granular neurons. We found a continuous postnatal decline of the neuronal form of pp60c-src, pp60+, in the cerebellum of both mutants concomitant with the degeneration of cerebellar granule cells. This indicates that granular neurons provide the main source for pp60+ in the cerebellar cortex.

Citations

Sep 1, 1994·Brain Research. Molecular Brain Research·M KambourisM E Hodes

Related Concepts

Cerebellum
Chakragati Mice
Nerve Degeneration
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Proto-Oncogenes
Western Blot
Proto-Oncogene Protein pp60 (c-src)

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