Progressive lung and cardiac changes associated with pulmonary hypertension in the fetal rat

Pediatric Pulmonology
V E FabrisJ Belik

Abstract

To determine the natural history of lung vascular remodeling and cardiac changes in the rat model of persistent pulmonary hypertension syndrome (PPHN) of the newborn, we studied fetal rats subjected to maternal indomethacin administration initiated on day 19 of gestation and continued for 2, 3, or 4 days. Animals receiving a similar volume of water or alcohol served as controls. Significant pulmonary hypertension was noted in the experimental group, as evidenced by a significantly increased right to left ventricular wall ratio to 1.6 +/- 0.1 in the 4-day treatment group, as compared with 1.2 +/- 0.4 in the control group (P < 0.01). The smooth muscle area for <25 microm external diameter arterial vessels was significantly increased (12.7 +/- 0.6 vs. 10.0 +/- 0.6 microm; P < 0.01) and the adventitial area of all diameters vessels was significantly greater (P < 0.01) following 3 days of indomethacin treatment, as compared with water controls. Associated with these changes, the 4-day treatment group's lung/body weight ratio was 0.021 +/- 0.001, and was significantly less (P < 0.01) than for the control group (0.035 +/- 0.001). This reduction in lung weight was not associated with changes in lung protein content or wet/dry weight ra...Continue Reading

Citations

Aug 19, 2007·American Journal of Respiratory and Critical Care Medicine·Enrica FornaroJaques Belik
May 21, 2013·Jornal de pediatria·Joaquim E B Cabral, Jaques Belik
Jul 22, 2010·Free Radical Biology & Medicine·Azhar MasoodA Keith Tanswell
Jul 3, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Azhar MasoodA Keith Tanswell
May 13, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Xue-Feng XuLi-Zhong Du

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