Progressive multifocal leucoencephalopathy

Italian Journal of Neurological Sciences
N J Dalsgaard HansenE Stenager

Abstract

Progressive multifocal leucoencephalopathy (PML) is a rarely occurring demyelinating disease of the central nervous system caused by a neurotropic papovavirus named JC virus (JCV). The most frequently affected affected regions are the cerebral hemispheres, especially the parietooccipital region, followed by the cerebellum and brain stem. The disease occurs predominantly in individuals with an immunocompromised state and impaired cellular mediated immunity (CMI) due to other underlying illness. More extensive use of irradiation and immunosuppressive therapy in relation to increased transplantational activities as well as treatment of autoimmune diseases and malignancies, in addition to the appearance of the acquired immunodeficiency syndrome (AIDS) as a consequence of infection with the human immunodeficiency virus (HIV), has caused a considerable increase in the occurrence of PML. The course of the disease is still most often rapidly progressive and fatal, but several cases with prolonged survival and even remission have been reported, and various antiviral treatments have been tried. The only drug that until now has shown favourable results is cytosine arabinoside. In HIV-infected PML-patients immunomodulation with AZT/zidovud...Continue Reading

References

May 1, 1992·The British Journal of Radiology·J V BowlerG D Perkin
Jan 1, 1991·Neurosurgical Review·K KuchelmeisterM Tegenthoff
Feb 4, 1988·The New England Journal of Medicine·E P Richardson
Dec 1, 1986·Acta Neurologica Scandinavica·S Helweg-LarsenP Arlien-Søborg
Sep 1, 1987·Journal of Neuropathology and Experimental Neurology·A J AksamitJ G Guccion
Oct 1, 1988·Acta Neurologica Scandinavica·G L StonerH D Webster
Nov 18, 1965·Acta Neuropathologica·L Silverman, L J Rubinstein
Apr 28, 1994·The New England Journal of Medicine·P J Weiss, J K DeMarco
Jan 1, 1955·Acta psychiatrica et neurologica Scandinavica·E CHRISTENSEN, M FOG
Oct 26, 1961·The New England Journal of Medicine·E P RICHARDSON

❮ Previous
Next ❯

Citations

Jun 19, 2008·European Radiology·Per-Ake Svensson, Elna-Marie Larsson
Apr 23, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Stefanie DahlhausRalf Gold
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·G StockhammerS Felber
May 17, 2005·Equine Veterinary Journal·J M SwainI G Mayhew

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.