PMID: 6987549Mar 1, 1980Paper

Progressive multifocal leukoencephalopathy (PML): in vitro cell-mediated immune responses to mitogens and JC virus

E WilloughbyB Dupont


Cell-mediated immunity was studied by in vitro tests in seven patients with progressive multifocal leukoencephalopathy (PML). Lymphocyte proliferation in response to mitogenic stimulation was reduced to a variable degree in all patients, indicating a general impairment of cell-mediated immune responsiveness, although mitogen-induced production of the lymphokine migration inhibitory factor (LIF) was normal in most cases. Cell-mediated immunity to JC virus (JCV) was assessed by LIF production in response to JCV antigen. In the six PML patients tested, LIF production with JCV antigen was absent despite the presence of antibody to JCV in serum. This contrasted with positive LIF production in seropositive normal individuals and patients and patients with other diseases. These results provide the first in vitro evidence of a depressed cell-mediated immune response to JCV in patients with PML, and support the hypothesis that PML is accompanied by a selective marked deficiency in cellular response to this virus in association with a general depression of cell-mediated immunity of variable severity.


Jan 1, 1996·Springer Seminars in Immunopathology·A R Pachner
Jan 1, 1988·Virus Research·M Rubino, D Walker
Jan 1, 1985·Clinical Neurology and Neurosurgery·J D SpeelmanB Verbeeten
Aug 1, 1985·Journal of Neuroimmunology·H BartfeldH Donnenfeld
Nov 21, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Shigeki TakedaHiroyuki Arai
May 16, 2002·Journal of Cellular Physiology·Thersa M SweetKamel Khalili
Oct 12, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Joseph R Berger
Apr 11, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ning-Sheng LaiWen-Yao Yin
Jul 29, 2008·Neurologic Clinics·Thomas Weber
Sep 1, 1983·Current Problems in Cancer·A M SpenceR Ruff
Jul 2, 2015·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Padmaja SudhakarSachin Kedar
May 1, 1983·Annals of Neurology·R W PriceD Walker
Oct 5, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Chandrashekar BohraSamir Dalia
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Igor J KoralnikNorman L Letvin

Related Concepts

Antigens, Viral
Cellular Immune Response
Leukocyte Migration-Inhibitory Factors
Leukoencephalopathy, Progressive Multifocal
Lymphocyte Activation

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.