Progressive multifocal leukoencephalopathy: molecular biology, pathogenesis and clinical impact

Intervirology
T Weber, E O Major

Abstract

The human polyomaviruses JC virus (JCV) and BK virus (BKV) have long been known as onco- and neurooncogenic. Interest in their oncogenic potential has reemerged with the discovery of simian virus 40 DNA in human brain tumors including the pituitary as well as in bone tumors and mesotheliomas. The only human disease caused by an infection with the human polyomavirus JCV is progressive multifocal leukoencephalopathy (PML) characterized by a lytic infection of oligodendrocytes with consecutive demyelination. Malignant transformation of cell lines appears to be caused by a complex interaction of the viral large T (tumor) antigen with several transcription factors and tumor suppressor proteins such as p53 and the retinoblastoma protein. PML, once an extremely rare disease, has become much more frequent in the western world owing to the AIDS pandemic. An exceedingly complicated, cell-, tissue- and species-specific pattern of protein-DNA interaction and negative as well as positive feedback regulation by at least a dozen proteins and possibly mutations in the JC viral promoter-enhancer region govern host range and development of PML. The intricate molecular and immunological prerequisites ultimately leading to PML in humans have not y...Continue Reading

Citations

May 15, 2002·Archives of Pharmacal Research·Hee-Sun Kim, Moon-Sook Woo
Dec 24, 2004·Transplant International : Official Journal of the European Society for Organ Transplantation·David ShitritMordechai R Kramer
Feb 20, 2008·Virchows Archiv : an International Journal of Pathology·Tomohiko KutsunaYasuo Takano
May 28, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yoshifumi AraiJunnosuke Yamamoto
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B GiudiciP Cinque
Jan 13, 2000·The American Journal of Surgical Pathology·O Cubukcu-DimopuloJ Jagirdar
Nov 24, 2006·The Neurologist·Allen J Aksamit
Dec 2, 2009·The Pediatric Infectious Disease Journal·David J HormozdiGregory A Storch
Dec 6, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M A SahraianA Minagar
Jun 6, 2009·Journal of Clinical Microbiology·John A VanchiereJanet S Butel
Sep 29, 2006·Journal of Virology·Laura A ShackeltonEdward C Holmes
Sep 12, 2000·Journal of Virology·N ArbourP J Talbot
Jun 15, 2004·Journal of Virology·Yasuko OrbaKazuo Nagashima
Jan 24, 2007·Journal of Clinical Pathology·Huachuan ZhengYasuo Takano
Nov 1, 2008·Journal of the Medical Library Association : JMLA·Michele R Tennant, Michael M Miyamoto
Jan 9, 2001·Annals of Transplantation : Quarterly of the Polish Transplantation Society·D HadjiliadisS M Palmer
Jul 29, 2008·Neurologic Clinics·Thomas Weber
Jan 1, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Serena DelbuePasquale Ferrante
Apr 25, 2006·Gastroentérologie Clinique Et Biologique·Sophie AlibertDanièle Botta-Fridlund
Nov 6, 2007·Molecular Phylogenetics and Evolution·Andrew KitchenConnie J Mulligan
May 6, 2003·Annals of Neurology·Conrad A MessamEugene O Major
Mar 24, 2007·Microbiology and Immunology·Yuji SundenHirofumi Sawa
May 31, 2007·The Journal of Pathology·H ZhengY Takano
Apr 16, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·T MouaC C Kennedy
Jun 20, 2012·Microbiology and Immunology·Tadaki SuzukiHirofumi Sawa
Aug 15, 2014·Brain Pathology·Pasquale DonnarummaRoberto Delfini
Jan 9, 2004·Clinics in Laboratory Medicine·José R Romero, David W Kimberlin
Feb 23, 2011·Revista Da Sociedade Brasileira De Medicina Tropical·Roberta Oliveira de Paula e SilvaLuciana Cristina dos Santos Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.